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Product Overview

Instgra is an antiretroviral medication containing Dolutegravir as its active component. As an integrase strand transfer inhibitor (INSTI), it plays a crucial role in HIV treatment by preventing the virus from replicating and infecting healthy cells. The medication inhibits the integrase enzyme that HIV requires for its multiplication process. Available in tablet form, Instgra is prescribed as part of combination therapy with other antiretroviral drugs for comprehensive HIV management.

Uses

This medication is approved for treating HIV-1 infection in patients aged 6 years and above, including both treatment-naive individuals and those with prior HIV treatment history. Instgra effectively lowers viral load, enhances CD4 cell counts, and strengthens immune system function. Its antiviral action helps delay HIV progression and minimizes the likelihood of developing AIDS-related complications.

How to Use

Take Instgra tablets orally once daily, with or without food. Swallow the tablet whole with water – do not crush, chew, or break it. Consistent daily dosing at the same time is recommended to maintain stable drug concentrations. Strict adherence to the prescribed regimen is crucial; never modify dosage or discontinue treatment without medical supervision, as this may compromise treatment efficacy and promote drug resistance.

How it Works

Dolutegravir, the active pharmaceutical ingredient, specifically targets and blocks the HIV integrase enzyme. This inhibition prevents viral DNA from integrating into host cell DNA, effectively stopping HIV replication. The mechanism reduces viral load while preserving immune function. With its high potency and resistance profile, Dolutegravir serves as a cornerstone in modern HIV treatment protocols.

Dosage and Administration

The standard dosage for adults and pediatric patients (≥6 years) is 50 mg once daily. Special populations or cases involving drug-resistant HIV strains may require dosage adjustments or combination therapies. Consistent daily administration is essential for optimal results. Patients with renal impairment or those taking interacting medications may need modified dosing regimens under medical supervision.

Benefits

Instgra provides multiple therapeutic advantages for HIV patients, including effective viral suppression and immune system preservation. Its once-daily dosing promotes treatment adherence, while its favorable safety profile enhances tolerability. The medication’s high genetic barrier to resistance makes it particularly valuable for long-term HIV management strategies.

Common Side Effects

Patients may experience mild-to-moderate adverse effects such as headaches, gastrointestinal disturbances (nausea, diarrhea), fatigue, sleep disturbances, or vivid dreams. These typically diminish with continued use. Serious reactions like hypersensitivity or hepatotoxicity occur rarely but require immediate medical attention if suspected.

Warnings

Potential serious risks include hypersensitivity reactions, hepatic impairment, and metabolic complications like lactic acidosis. Significant drug interactions may occur with rifampin, antacids, and certain anticonvulsants. Pregnancy requires careful risk-benefit assessment, as Dolutegravir may affect fetal development. Always disclose all medications and medical conditions to your healthcare provider before starting treatment.

Storage Information

Maintain tablets at controlled room temperature (20°C-25°C/68°F-77°F) in their original packaging, protected from moisture and heat. Keep away from children and avoid storage in humid areas like bathrooms. Dispose of unused or expired medication according to local pharmaceutical waste guidelines.

Disclaimer:

This information is provided for educational purposes only and represents expert-reviewed, accurate content. It does not substitute professional medical advice, diagnosis, or treatment. Consult your physician regarding any health concerns, potential drug interactions, or complete safety information. This content aims to supplement, not replace, the essential relationship between patients and their healthcare providers.