Product Overview
Gate P is a combination ophthalmic solution containing Gatifloxacin (an antibiotic) and Prednisolone (a steroid). This dual-action medication effectively treats bacterial eye infections while simultaneously reducing inflammation. The formulation works by eliminating infection-causing bacteria and alleviating inflammatory responses in ocular tissues.
Indications
Gate P is indicated for:
– Bacterial conjunctivitis (pink eye)
– Keratitis (corneal inflammation)
– Blepharitis (eyelid inflammation)
– Post-operative ocular inflammation
– Uveitis and iritis (inflammatory eye conditions)
It effectively addresses symptoms including ocular redness, swelling, pain, discharge, and photophobia.
Administration Guidelines
- Wash hands thoroughly before administration
- Tilt head backward and gently pull lower eyelid downward
- Instill prescribed drops into the conjunctival sac
- Close eyes gently for 1-2 minutes after instillation
- Apply gentle pressure to the lacrimal sac for 1 minute (prevents systemic absorption)
- Wait 5 minutes before administering other eye medications
Mechanism of Action
Component | Action |
---|---|
Gatifloxacin | Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, disrupting DNA replication in susceptible bacteria |
Prednisolone | Suppresses inflammatory response by inhibiting phospholipase A2, reducing prostaglandin and leukotriene production |
Dosage Protocol
Standard Dosage:
– Days 1-2: 1-2 drops every 2 hours (while awake)
– Days 3-7: 1-2 drops 4 times daily
– Maximum duration: 10 days (unless directed otherwise)
Pediatric Use:
– Safety established for children ≥1 year
– Use under medical supervision
Therapeutic Advantages
- Synergistic antibacterial and anti-inflammatory action
- Broad-spectrum coverage against common ocular pathogens
- Rapid symptomatic relief (within 24-48 hours)
- Convenient dosing regimen
- Minimal systemic absorption
Adverse Effects
Common (≥1%):
– Transient ocular burning/stinging (15-20%)
– Blurred vision (5-10%)
– Foreign body sensation
– Mild conjunctival hyperemia
Rare (<1%):
– Corneal deposits
– Elevated intraocular pressure
– Superinfection
– Allergic reactions
Precautions
Contraindications:
– Viral/fungal ocular infections
– Known hypersensitivity to quinolones or steroids
– Corneal epithelial defects (unless supervised)
Special Populations:
– Pregnancy Category C: Use only if potential benefit justifies risk
– Lactation: Exercise caution
– Elderly: Monitor for steroid-induced glaucoma
Storage Conditions
– Store at 15-25°C
– Protect from light
– Discard 4 weeks after opening
– Do not use if solution changes color or becomes cloudy
Important Safety Information
Prolonged use may result in:
– Ocular hypertension/glaucoma
– Posterior subcapsular cataract formation
– Secondary ocular infections
– Delayed wound healing
Regular intraocular pressure monitoring recommended during extended therapy.
Medical Disclaimer
This information is intended for healthcare professionals and educated patients. The content does not replace professional medical advice, diagnosis, or treatment. Always consult your ophthalmologist regarding any questions about ocular conditions or medications. Individual patient responses may vary based on clinical circumstances.
Reviews
There are no reviews yet