Sorbitrate

Product Overview

Sorbitrate is a medication containing the active ingredient Isosorbide, which belongs to the class of drugs known as nitrates. It is commonly prescribed for the management of angina pectoris, a condition characterized by chest pain or discomfort due to reduced blood flow to the heart muscle. Sorbitrate works by dilating the blood vessels, which helps to increase blood flow to the heart and reduce the workload on the heart, thereby relieving chest pain associated with angina.

Uses

Sorbitrate is primarily used for the treatment and prevention of angina pectoris, including chronic stable angina and variant angina (Prinzmetal’s angina). It is often prescribed as part of a comprehensive treatment regimen for individuals with coronary artery disease to reduce the frequency and severity of angina attacks. Sorbitrate may also be used off-label for other conditions such as congestive heart failure and pulmonary hypertension, under the supervision of a healthcare provider.

How to Use

Sorbitrate is typically taken orally as directed by a healthcare provider. The tablets should be placed under the tongue and allowed to dissolve completely, without chewing or swallowing, to facilitate rapid absorption into the bloodstream. It is important to follow the dosing instructions provided by the healthcare provider and not to exceed the recommended dosage. Sorbitrate may be taken with or without food, but consistent timing of doses is important for optimal therapeutic effects.

How it Works

Sorbitrate works by releasing nitric oxide, which activates guanylate cyclase enzyme in smooth muscle cells. This leads to the formation of cyclic guanosine monophosphate (cGMP), which causes relaxation of vascular smooth muscle and dilation of blood vessels, particularly veins. By dilating the blood vessels, Sorbitrate reduces peripheral vascular resistance and venous return, which decreases preload and oxygen demand on the heart, ultimately improving blood flow to the heart muscle.

Dosage and Administration

The dosage of Sorbitrate varies depending on the individual’s medical condition, response to treatment, and other factors. It is typically started at a low dose and gradually increased as tolerated to achieve the desired therapeutic effect. The usual adult dosage of Sorbitrate for angina is 5 to 40 mg sublingually or orally every 4 to 6 hours as needed. Dosage adjustments may be necessary in elderly patients and those with impaired renal or hepatic function.

Benefits

The benefits of Sorbitrate include its ability to relieve chest pain associated with angina, improve exercise tolerance, and enhance quality of life for individuals with coronary artery disease. By dilating the blood vessels and increasing blood flow to the heart, Sorbitrate helps to reduce the frequency and severity of angina attacks, allowing patients to engage in daily activities with greater comfort and confidence.

Common Side Effects

Common side effects associated with the use of Sorbitrate may include headache, dizziness, lightheadedness, flushing, and nausea. These side effects are usually transient and may diminish with continued use of the medication. However, some individuals may experience more serious side effects such as hypotension (low blood pressure), syncope (fainting), or reflex tachycardia (rapid heart rate), which may require medical attention.

Warnings

Sorbitrate should be used with caution in individuals with hypotension, hypovolemia, or severe anemia, as it may further lower blood pressure and exacerbate these conditions. It should be avoided in patients with acute myocardial infarction (heart attack), severe aortic stenosis, or hypertrophic obstructive cardiomyopathy, as it may worsen cardiac ischemia or heart failure. Sorbitrate may interact with certain medications such as phosphodiesterase inhibitors, antihypertensive agents, and alcohol, leading to additive hypotensive effects.

Storage Information

Sorbitrate tablets should be stored at room temperature between 20°C to 25°C (68°F to 77°F), away from moisture and heat. It is important to keep it out of reach of children and pets. Do not store it in the bathroom or near the kitchen sink, as moisture and humidity may affect its stability. If the medication is outdated or no longer needed, it should be disposed of properly according to local regulations.

Disclaimer:

Our sole intention is to ensure that its consumers get information that is expert-reviewed, accurate, and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions, or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.