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Product Overview

Lurafic is a prescription medication containing the active ingredient Lurasidone, classified as an atypical antipsychotic. It is clinically approved for the treatment of schizophrenia and bipolar depression. Lurasidone functions by regulating neurotransmitter activity in the brain, particularly dopamine and serotonin, which play crucial roles in mood stabilization and the management of psychotic symptoms. Available in oral tablet formulation, Lurafic requires professional medical supervision for proper use.

Therapeutic Applications

Lurafic is indicated for:
– Management of schizophrenia symptoms (including hallucinations, delusions, and cognitive disturbances)
– Treatment of depressive episodes associated with bipolar I disorder (as monotherapy or adjunctive therapy)
The medication helps restore neurotransmitter balance, improving patients’ functional capacity and quality of life.

Administration Guidelines

1. Take orally once daily with food (preferably with evening meal)
2. Swallow tablets whole with water (do not crush, chew, or split)
3. Maintain consistent dosing schedule
4. Continue treatment as prescribed, even with symptom improvement
5. Allow 2-6 weeks for full therapeutic effect
6. Consult healthcare provider before making dosage changes

Mechanism of Action

Lurasidone demonstrates:
– High affinity for dopamine D2 and serotonin 5-HT2A receptors (antagonist activity)
– Partial agonist activity at serotonin 5-HT1A receptors
– Minimal histaminergic or muscarinic activity
This unique receptor profile contributes to its efficacy with potentially fewer metabolic side effects compared to other antipsychotics.

Dosage Protocol

Schizophrenia:
– Initial: 40 mg daily
– Maintenance: 40-160 mg daily
– Maximum: 160 mg daily

Bipolar Depression:
– Initial: 20 mg daily
– Maintenance: 20-120 mg daily
– Maximum: 120 mg daily

Special Populations:
– Hepatic impairment: Reduce initial dose by 50%
– CYP3A4 interactions: Adjust dose when used with strong inhibitors/inducers

Therapeutic Advantages

1. Effective symptom control for both psychotic and mood disorders
2. Favorable metabolic profile (lower weight gain risk)
3. Once-daily dosing improves compliance
4. Minimal anticholinergic effects
5. Improved cognitive functioning in some patients

Adverse Effects

Most common (≥5% incidence):
– Somnolence (drowsiness)
– Akathisia (restlessness)
– Nausea
– Parkinsonism
– Anxiety

Generally dose-dependent and often transient. Management strategies include dose adjustment or symptomatic treatment.

Important Precautions

Black Box Warnings:
– Increased mortality in elderly dementia patients
– Suicidality risk in young adults

Additional precautions:
– Neuroleptic malignant syndrome monitoring
– Tardive dyskinesia risk assessment
– Orthostatic hypotension precautions
– Hyperglycemia/dyslipidemia monitoring
– Seizure threshold considerations

Storage Requirements

1. Store at 20-25°C (68-77°F)
2. Protect from moisture and light
3. Keep in original packaging
4. Secure storage away from children/pets
5. Properly dispose unused medication via take-back programs

Medical Disclaimer

This information serves educational purposes only and does not constitute medical advice. While we strive for accuracy, this content:
– Is not exhaustive
– May not reflect latest research
– Should not replace professional consultation
Patients must consult qualified healthcare providers for:
– Personalized treatment plans
– Complete safety information
– Ongoing monitoring
We support collaborative doctor-patient relationships for optimal therapeutic outcomes.