Trental 400

Product Overview

Trental 400 is a prolonged-release tablet containing the active ingredient Pentoxifylline, a hemorrheologic agent that enhances blood circulation by reducing viscosity. This medication is specifically designed to treat peripheral vascular diseases, such as intermittent claudication, where restricted blood flow to the limbs causes discomfort. By optimizing blood circulation, Trental 400 alleviates symptoms like leg pain and cramping, enabling patients to perform daily activities with greater ease.

Uses

Trental 400 is primarily prescribed to manage symptoms of peripheral vascular diseases, particularly intermittent claudication—a condition marked by leg pain, cramping, or weakness during physical exertion due to insufficient blood supply. The medication improves blood flow to affected areas, reducing discomfort and increasing the distance patients can walk before symptoms arise.

How to Use

Follow your healthcare provider’s instructions precisely when taking Trental 400. The standard dosage is one 400 mg prolonged-release tablet taken orally three times daily with meals. Swallow the tablet whole with water—do not crush, chew, or break it, as this disrupts its extended-release mechanism. Consistent daily dosing at the same times ensures stable therapeutic levels in the body.

How It Works

Trental 400 enhances peripheral blood flow through vasodilation and improved rheological properties. Its active ingredient, Pentoxifylline, inhibits phosphodiesterase, elevating cyclic adenosine monophosphate (cAMP) levels in vascular smooth muscle cells. This relaxes blood vessels, dilates arteries, and boosts circulation to the extremities. Additionally, Trental 400 reduces blood viscosity, improving microcirculation and oxygen delivery to tissues.

Dosage and Administration

The recommended dose is one 400 mg prolonged-release tablet taken three times daily with meals. Your doctor may adjust the dosage based on your response and symptom severity. Adherence to prescribed dosing is crucial for optimal results.

Benefits

Trental 400 provides significant relief for peripheral vascular disease patients, reducing leg pain, cramping, and weakness linked to intermittent claudication. By enhancing blood flow, it increases walking endurance and activity tolerance, improving overall quality of life. The prolonged-release formulation ensures consistent therapeutic effects throughout the day.

Common Side Effects

Possible side effects include mild gastrointestinal issues (nausea, vomiting, diarrhea, abdominal discomfort), headache, dizziness, flushing, or palpitations. These are typically temporary and diminish with continued use. Consult your doctor if side effects persist or worsen.

Warnings

Inform your healthcare provider of any medical conditions, allergies, or medications (especially anticoagulants or antiplatelet drugs) before using Trental 400. The medication may increase bleeding risk, particularly in those with bleeding disorders or on blood thinners. Pregnant or breastfeeding women should seek medical advice before use.

Storage Information

Store Trental 400 at room temperature, away from moisture, heat, and light. Keep it out of reach of children and pets. Avoid storing in humid areas like bathrooms or near sinks. Check the expiration date and dispose of expired or unused tablets properly.

Disclaimer:

Our goal is to provide expert-reviewed, accurate, and reliable information. However, this content should NOT replace professional medical advice. The details here are for informational purposes only and may not cover all possible side effects, interactions, or warnings. Always consult your physician for personalized guidance. This information supports—but does not substitute—the doctor-patient relationship.