Encore

Product Overview

Encorate is a pharmaceutical preparation containing Sodium Valproate (200mg) as its active component. The medication is formulated as an enteric-coated tablet, engineered to dissolve in the intestinal tract rather than the stomach, thereby minimizing potential gastric irritation. This antiepileptic drug (AED) is primarily indicated for the management of epilepsy, bipolar disorder, and migraine prophylaxis. As a member of the anticonvulsant class, it functions as both a seizure suppressant and mood stabilizer.

Therapeutic Applications

Encorate is principally prescribed for seizure control across various epilepsy types, including generalized tonic-clonic, absence, and partial seizures. Additionally, it serves as an effective therapeutic option for manic episodes in bipolar disorder and as a preventive treatment for migraine headaches. The medication achieves these effects by regulating neurotransmitter activity within the central nervous system, thereby stabilizing neuronal excitability and mood patterns.

Administration Guidelines

For optimal results, Encorate tablets should be ingested whole with an adequate amount of water, preferably during meals to enhance gastrointestinal tolerance. The enteric coating must remain intact; therefore, tablets should not be crushed, chewed, or divided prior to consumption. Strict adherence to the prescribed dosing schedule is essential to maintain therapeutic drug levels and achieve desired clinical outcomes.

Mechanism of Action

The pharmacological activity of Encorate stems from its ability to potentiate gamma-aminobutyric acid (GABA) neurotransmission, the primary inhibitory neurotransmitter in the central nervous system. Sodium Valproate enhances GABAergic inhibition while simultaneously modulating voltage-gated sodium channels and other neurotransmitter systems. This dual mechanism effectively suppresses abnormal neuronal discharge in epilepsy and stabilizes mood fluctuations in bipolar disorder.

Dosage Protocol

Encorate dosing requires careful individualization based on multiple factors including patient age, body mass, clinical indication, and therapeutic response. Treatment typically commences with conservative dosing followed by gradual titration to achieve optimal efficacy while minimizing adverse effects. Regular clinical assessment and potential dosage adjustments should be conducted under medical supervision to maintain therapeutic benefit.

Therapeutic Advantages

• Effective seizure control in multiple epilepsy types
• Mood stabilization in bipolar affective disorder
• Prophylactic management of migraine episodes
• Enteric-coated formulation reduces gastric irritation
• Simplified dosing regimen for improved compliance

Potential Adverse Effects

Common adverse reactions associated with Encorate therapy may include central nervous system effects (drowsiness, dizziness), gastrointestinal disturbances (nausea, abdominal discomfort), and metabolic changes (weight fluctuation). While these effects are typically dose-dependent and transient, persistent or severe symptoms warrant medical evaluation. Regular monitoring may be necessary to manage these effects appropriately.

Precautions and Contraindications

Special caution is advised when prescribing Encorate to patients with hepatic impairment, pancreatic disorders, or hematological abnormalities. Absolute contraindications include known hypersensitivity to valproate compounds. The medication carries significant teratogenic potential, necessitating thorough risk-benefit analysis for women of childbearing potential. Routine laboratory monitoring of hepatic function and hematological parameters is recommended during treatment.

Storage Requirements

Maintain Encorate tablets in their original packaging at controlled room temperature (15-30°C), protected from humidity and light exposure. Ensure secure storage away from pediatric access. Discard any medication beyond its expiration date, as indicated on the packaging, to guarantee pharmaceutical integrity and therapeutic efficacy.

Medical Disclaimer:

The information provided herein is intended for educational purposes only and represents current medical knowledge regarding this pharmaceutical product. This content does not encompass all potential adverse effects, contraindications, or drug interactions. It should not substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or therapeutic regimen. This information aims to facilitate informed discussions between patients and their healthcare providers, not to replace clinical judgment.