Otoflu Eye/Ear Drops

Product Overview

Otoflu Eye/Ear Drops is a sterile antifungal solution containing Fluconazole (0.3% w/v) for topical ocular and otic use. This specialized formulation is clinically proven to treat fungal infections affecting the eyes and ears, delivering targeted therapeutic action to combat pathogenic fungi while relieving associated symptoms. The dropper bottle design ensures precise, contamination-free application.

Uses

Clinically indicated for fungal infections (mycoses) of ocular and aural structures caused by Candida, Aspergillus, and other susceptible fungi. Effective against symptoms including erythema, pruritus, abnormal discharge, edema, and discomfort. The topical formulation ensures direct delivery of antifungal agents to infected tissues while minimizing systemic absorption.

How to Use

1. Perform thorough hand hygiene before administration
2. For ocular use: Tilt head back, gently pull lower eyelid downward to form conjunctival sac
3. For otic use: Position affected ear upward, gently retract auricle
4. Instill prescribed drops without contacting applicator tip to any surface
5. Maintain position for 30 seconds post-application
6. Recap bottle immediately after use

Mechanism of Action

Fluconazole exerts fungistatic and fungicidal effects through selective inhibition of fungal cytochrome P450-dependent 14α-lanosterol demethylase. This disrupts ergosterol biosynthesis, compromising fungal cell membrane integrity and permeability. The resultant depletion of ergosterol and accumulation of toxic sterol intermediates leads to fungal cell lysis.

Dosage and Administration

Standard dosage regimen:
– Ophthalmic: 1 drop in affected eye(s) every 4-6 hours
– Otic: 2-3 drops in affected ear twice daily

Treatment duration typically 7-14 days based on clinical response. Complete full prescribed course even if symptoms resolve earlier. Dosage adjustments may be required for pediatric or immunocompromised patients.

Therapeutic Advantages

• Broad-spectrum antifungal coverage
• Rapid symptomatic relief
• Optimized topical bioavailability
• Preservative-free formulation minimizes irritation
• Sterile, isotonic solution compatible with ocular/otic tissues

Adverse Effects

Generally well-tolerated with minimal adverse effects. May include:
– Transient application site reactions (burning/stinging ≤2 minutes)
– Mild hyperemia
– Epiphora (excessive tearing)
– Pruritus
Discontinue if severe irritation, pain, or vision changes occur.

Precautions

Contraindicated in patients with known hypersensitivity to azole derivatives. Not for use with perforated tympanic membranes. Avoid contact lens wear during ocular treatment. Monitor for superinfections with prolonged use. Pregnancy Category C – use only if potential benefit justifies potential risk.

Storage Conditions

Maintain at controlled room temperature (15-30°C). Protect from light and excessive moisture. Discard 28 days after opening. Do not refrigerate or freeze. Keep container tightly closed.

Disclaimer:

This information is provided for educational purposes only and does not constitute medical advice. The content has been reviewed by healthcare professionals but may not encompass all possible precautions, interactions, or adverse effects. Always consult your physician before initiating any treatment. Individual patient responses may vary. This product should be used as part of a comprehensive treatment plan under medical supervision.