Acular LS Eye Drops

Product Overview

Acular LS Drop is a sterile ophthalmic solution containing the active pharmaceutical ingredient Ketorolac tromethamine. This prescription medication is specifically designed to manage ocular inflammation and discomfort resulting from allergic conjunctivitis or post-surgical procedures. As a topical NSAID (nonsteroidal anti-inflammatory drug), Acular LS Drop effectively reduces pain and inflammatory responses in ocular tissues, promoting visual comfort and recovery.

Therapeutic Applications

This medication is clinically indicated for:

• Post-operative inflammation management following cataract extraction or refractive eye surgery
• Symptomatic relief of ocular pruritus and erythema in seasonal allergic conjunctivitis

The formulation exerts its therapeutic effect by selectively inhibiting cyclooxygenase-mediated prostaglandin synthesis, thereby modulating the inflammatory cascade in ocular tissues.

Administration Guidelines

For optimal results:

1. Perform thorough hand hygiene before administration
2. Assume a reclined position and gently retract the lower eyelid to form a conjunctival sac
3. Position the dropper vertically above the eye without corneal contact
4. Instill the prescribed number of drops into the inferior cul-de-sac
5. Maintain eyelid closure for 30 seconds post-instillation
6. Apply digital pressure to the lacrimal sac for 1 minute to minimize systemic absorption

Note: Strict aseptic technique should be maintained throughout the procedure.

Mechanism of Action

Ketorolac tromethamine demonstrates potent NSAID activity through competitive inhibition of cyclooxygenase (COX) isoenzymes, particularly COX-1 and COX-2. This pharmacological action results in:

• Decreased synthesis of inflammatory prostaglandins
• Reduction in vasodilation and vascular permeability
• Attenuation of nociceptive signaling
• Modulation of inflammatory cell migration

Dosage Protocol

Note: Therapy should not exceed prescribed duration without ophthalmological evaluation.

Therapeutic Advantages

• Rapid onset of anti-inflammatory action (within 30 minutes)
• Effective reduction of post-surgical photophobia and discomfort
• Significant improvement in ocular comfort scores
• Preservative-free formulation minimizing irritative potential
• Demonstrated safety profile in geriatric populations

Adverse Effects

Common ocular adverse reactions (incidence >5%) include:

• Transient ocular burning/stinging (typically <2 minutes duration)
• Conjunctival hyperemia
• Corneal punctate staining
• Epithelial keratopathy

Systemic absorption may rarely cause headache or gastrointestinal discomfort.

Precautions and Contraindications

Important safety considerations:

• Contraindicated in patients with NSAID hypersensitivity or aspirin-sensitive asthma
• Defer contact lens wear until 15 minutes post-instillation
• Exercise caution in patients with:
  • Coagulation disorders
  • Active peptic ulcer disease
  • Renal impairment
• May potentiate ocular hemorrhage in traumatic injuries

Storage Requirements

• Maintain at controlled room temperature (15-30°C)
• Protect from light exposure
• Discard 28 days after initial opening
• Do not store in bathroom environments

Medical Disclaimer

The information provided herein represents current pharmacological data but does not constitute medical advice. This monograph is intended for educational purposes only and should not replace professional clinical judgment. Healthcare providers should reference the full prescribing information and consider individual patient factors when making therapeutic decisions. Patients are advised to consult their ophthalmologist regarding any concerns about their ocular health or medication regimen.