Erythromycin

Product Description

Althrocin is a pharmaceutical preparation containing Erythromycin as its active component. This macrolide antibiotic is indicated for the treatment of diverse bacterial infections. Manufactured by Alembic Pharmaceuticals Ltd., this formulation is available in various dosage forms.

Therapeutic Indications

Althrocin is clinically prescribed for managing bacterial infections affecting multiple systems including respiratory, dermatological, soft tissue, and ocular infections. Additionally, it serves as prophylactic therapy against streptococcal infections in penicillin-allergic patients with rheumatic heart disease.

Administration Guidelines

For optimal absorption, administer Althrocin orally on an empty stomach (pre-meal), adhering strictly to the prescribed dosing schedule. Dosage adjustments should only be made under medical supervision to prevent potential adverse effects associated with improper dosing.

Mechanism of Action

The therapeutic efficacy of Althrocin stems from its bacteriostatic action through selective inhibition of the 50S ribosomal subunit. This molecular interaction disrupts peptide chain elongation during bacterial protein synthesis, thereby arresting microbial proliferation.

Therapeutic Advantages

Althrocin demonstrates broad-spectrum antimicrobial activity against Gram-positive and some Gram-negative organisms. Its principal clinical advantage lies in providing an effective penicillin-alternative for β-lactam sensitive patients while maintaining comparable therapeutic outcomes.

Adverse Reactions

Common adverse drug reactions include gastrointestinal manifestations (nausea, emesis, abdominal pain, diarrhea). Rare but serious complications may include pseudomembranous colitis secondary to Clostridium difficile overgrowth. Persistent symptoms warrant immediate medical consultation.

Dosage Protocol

Standard adult dosing regimen: 250-500mg every 6 hours (q6h) preprandially, with potential dose escalation in severe infections. Pediatric dosing is weight-adjusted (30-50mg/kg/day in divided doses). Strict adherence to prescribed regimens ensures optimal therapeutic outcomes.

Precautions and Contraindications

Pre-therapy screening should include hepatic/renal function assessment and allergy history. Caution is advised in patients with pre-existing cardiac conditions (potential QT prolongation). Pregnancy category B – use only when potential benefits outweigh risks under medical supervision.

Storage Conditions

Maintain product integrity by storing at controlled room temperature (15-30°C) in original packaging, protected from humidity and light exposure. Properly dispose of expired medications according to local pharmaceutical waste regulations. Keep all medications secured away from pediatric access.