Angiplat

Product Overview

Angiplat is a nitrate-based vasodilator containing Nitroglycerin as its active component. This prescription medication is primarily indicated for the treatment and prevention of angina pectoris – chest pain resulting from reduced cardiac blood flow. Available in sublingual tablets, oral sprays, and transdermal delivery systems, Angiplat functions by relaxing vascular smooth muscles to enhance coronary circulation and myocardial oxygen supply. It serves as both immediate relief for acute angina episodes and prophylactic therapy for chronic coronary artery disease patients.

Therapeutic Applications

Clinically, Angiplat is prescribed for:
• Acute termination of angina attacks (sublingual forms)
• Prophylaxis against anticipated angina (transdermal forms)
• Management of chronic stable angina
• Treatment of unstable angina (as adjunct therapy)
The medication effectively alleviates ischemic chest pain by improving coronary perfusion and reducing cardiac workload.

Administration Guidelines

For optimal results:
Sublingual administration:
1. Place tablet under tongue at first angina symptoms
2. Allow complete dissolution (avoid swallowing/sucking)
3. May repeat after 5 minutes if pain persists (max 3 doses)
Transdermal application:
1. Apply to hairless, clean chest/upper arm area
2. Rotate application sites daily
3. Remove old patch before applying new one
4. Maintain 10-12 hour nitrate-free period daily

Mechanism of Action

Angiplat’s active metabolite, nitric oxide, induces:
• Venodilation → reduced cardiac preload
• Arterial relaxation → decreased afterload
• Coronary vasodilation → improved myocardial perfusion
This triple action decreases myocardial oxygen demand while increasing supply, effectively breaking the ischemic cycle causing anginal pain.

Dosing Protocol

Acute therapy:
• Initial: 0.3-0.6 mg sublingually
• May repeat q5min (max 1.2 mg within 15 min)
Prophylactic therapy:
• Transdermal: 0.2-0.8 mg/hr system applied daily
• Titrate based on therapeutic response
Note: Always maintain minimum 8-hour nitrate-free interval to prevent tolerance.

Therapeutic Advantages

Angiplat provides:
• Rapid onset (1-3 minutes sublingually)
• Predictable hemodynamic effects
• Multiple administration options
• Established safety profile
• Cost-effective angina management
The medication significantly improves exercise tolerance and quality of life in CAD patients.

Adverse Effects

Frequently observed reactions include:
• Cephalgia (nitrate headache)
• Orthostatic hypotension
• Cutaneous flushing
• Reflex tachycardia
• Dizziness/lightheadedness
These typically diminish with continued use and proper hydration.

Important Precautions

Contraindications include:
• Concomitant PDE5 inhibitor use
• Severe aortic stenosis
• Cardiac tamponade
• Hypertrophic cardiomyopathy
Special caution required in:
• Elderly patients
• Hepatic impairment
• Hypothyroidism
• Malnutrition cases

Storage Requirements

• Tablets: Tight container, ≤30°C
• Spray: Upright position, avoid freezing
• Patches: Original packaging, room temperature
All forms should be protected from light and moisture. Discard tablets if discolored.

Medical Disclaimer

This informational content has been carefully reviewed by healthcare professionals but should not replace personalized medical advice. While we strive for accuracy, pharmaceutical knowledge evolves continuously. Always:
• Consult your cardiologist before use
• Disclose all concomitant medications
• Report unusual symptoms immediately
• Follow prescribed regimen strictly
This material supports but doesn’t substitute the physician-patient relationship.