Candifem Vaginal Cream

Product Overview

Candifem Vaginal Cream is a dual-action antifungal and antibacterial medication containing Miconazole and Ornidazole. This specialized formulation effectively combats vaginal infections caused by both fungal and bacterial microorganisms. The cream provides localized treatment for symptoms including vaginal itching, burning sensations, inflammation, and unusual discharge. Designed for intravaginal application, it offers a clinically proven solution for restoring vaginal flora balance and comfort.

Therapeutic Indications

This medication is clinically indicated for:
• Vulvovaginal candidiasis (yeast infections)
• Bacterial vaginosis
• Mixed vaginal infections
It effectively addresses associated symptoms such as pruritus, dysuria, erythema, edema, and pathological vaginal discharge by targeting the causative microorganisms.

Administration Guidelines

1. Perform hand hygiene and cleanse the perineal area
2. Prepare the single-dose applicator as per instructions
3. Assume a comfortable position (lying down or standing with knees bent)
4. Insert the applicator gently into the vaginal canal
5. Depress the plunger completely to deliver the medication
6. Clean the applicator after each use
Recommended treatment duration: 7-14 days (typically once daily at bedtime)

Mechanism of Action

Miconazole:
• Azole antifungal agent
• Inhibits ergosterol biosynthesis
• Disrupts fungal cell membrane integrity
• Fungistatic and fungicidal activity

Ornidazole:
• Nitroimidazole derivative
• Generates cytotoxic radicals in anaerobic organisms
• Causes DNA strand breaks in susceptible bacteria
• Effective against anaerobic bacteria and protozoa

Dosage Protocol

Standard therapeutic regimen:
• 5g cream intravaginally once daily
• Treatment duration:
– Mild infections: 7 days
– Moderate-severe infections: 14 days
• Complete full course even if symptoms resolve earlier
• Consult healthcare provider for pediatric/adolescent dosing

Therapeutic Advantages

• Dual antimicrobial spectrum coverage
• Rapid symptomatic relief (within 24-48 hours)
• Restores normal vaginal pH
• Convenient once-daily dosing
• Minimal systemic absorption
• Clinically proven efficacy (>90% cure rates)

Adverse Effects

Common (1-10% users):
• Transient local irritation
• Mild burning sensation
• Contact dermatitis
• Increased discharge

Rare (<1% users): • Vulvar edema • Urticaria • Systemic allergic reactions

Precautions

Contraindications:
• Hypersensitivity to imidazole derivatives
• First trimester pregnancy

Special populations:
• Pregnancy (Category C)
• Lactation (consult physician)
• Renal/hepatic impairment (monitor)

Drug interactions:
• Warfarin (may potentiate effects)
• Oral hypoglycemics (monitor glucose)

Storage Conditions

• Temperature: 15-30°C
• Protect from moisture
• Do not refrigerate
• Shelf life: 24 months from manufacture
• Discard unused portion after treatment completion

Medical Disclaimer

The information provided is for educational purposes only and does not constitute medical advice. While we strive for accuracy, this content is not exhaustive regarding all possible precautions, interactions, or adverse effects. Always:
1. Consult your healthcare provider before use
2. Disclose your complete medical history
3. Report any unexpected symptoms
4. Complete prescribed treatment course
This information supplements but does not replace professional medical judgment.