Propranolol

✅ Controls high blood pressure
✅ Prevents heart attacks
✅ Reduces migraine frequency
✅ Manages angina pectoris
✅ Treats tremors effectively

Ciplar contains Propranolol

Ciplar Tablet is prescribed to reduce anxiety and alleviate tremors. It’s also effective in preventing migraines, angina (heart-related chest pain), and stomach bleeding caused by portal hypertension (high blood pressure in the liver).

This medication may additionally be used to manage hypertension and certain cardiac arrhythmias. The dosage varies based on your condition and response to treatment. Always follow your doctor’s prescription precisely. For optimal absorption, take it on an empty stomach at consistent times daily. Continue treatment even when feeling well, as the therapeutic benefits persist. Abrupt discontinuation may worsen your condition.

Common side effects include fatigue, weakness, cold extremities (Raynaud’s phenomenon), bradycardia, finger numbness, and dyspnea. Gastrointestinal disturbances like nausea, vomiting, and diarrhea may also occur. Consult your physician if side effects persist or become bothersome. Most adverse effects are transient and diminish with continued use.

Contraindications include asthma, severe bradycardia, and advanced heart failure. Exercise caution with renal/hepatic impairment or COPD. Alcohol may interfere with medication efficacy and should be avoided. Refrain from driving if experiencing dizziness. Pregnant or breastfeeding women should seek medical advice before use.

THERAPEUTIC INDICATIONS

  • Pheochromocytoma management
  • Hypertension control
  • Migraine prophylaxis
  • Anxiety disorders
  • Cardiac arrhythmias
  • Myocardial infarction prevention
  • Angina pectoris prevention
  • Essential tremor management

CLINICAL BENEFITS

Pheochromocytoma Surgical Management

During pheochromocytoma resection, Ciplar Tablet mitigates catecholamine-induced hypertensive crises by competitively blocking β-adrenergic receptors. This pharmacological action reduces myocardial contractility and heart rate, effectively controlling blood pressure. Its rapid onset makes it invaluable for hypertensive emergencies, significantly lowering cardiovascular and renal complication risks.

ADVERSE EFFECTS PROFILE

Most adverse reactions are self-limiting and resolve with continued therapy. Seek medical advice if symptoms persist or cause concern.

Frequently Reported Reactions

  • Fatigue
  • Asthenia
  • Peripheral vasoconstriction
  • Cardiac conduction abnormalities
  • Gastrointestinal distress
  • Emesis
  • Loose stools

ADMINISTRATION GUIDELINES

Administer exactly as prescribed. Swallow tablets whole without chewing or crushing. For optimal bioavailability, take preprandially (before meals). Concomitant consumption with high-lipid foods (including olive oil, nuts, chocolate, and animal fats) may impair absorption.

PHARMACODYNAMICS

Ciplar Tablet’s active component, propranolol, is a nonselective β-adrenergic antagonist. It modulates sympathetic nervous system activity by competitively inhibiting catecholamine binding at β₁ and β₂ receptors. This results in negative chronotropic and inotropic effects, improving cardiac output in arrhythmias. Peripheral vasodilation occurs through reduced renin secretion and central sympathetic outflow, benefiting both angina and migraine prophylaxis. The anti-tremor mechanism, though not fully elucidated, likely involves suppression of peripheral β₂-mediated muscle activation. In anxiety management, it attenuates adrenergic hyperactivation by blocking epinephrine/norepinephrine effects. For pheochromocytoma, it provides perioperative hemodynamic stability by preventing catecholamine surges.

Medical Disclaimer:

This content is intended for informational purposes only, having been reviewed by medical professionals. It should not substitute for professional medical advice, diagnosis, or treatment. The information provided may not encompass all potential adverse effects, contraindications, or drug interactions. Always consult your healthcare provider regarding any medical condition or therapeutic regimen. This resource aims to complement, not replace, the crucial relationship between patients and their physicians.
Strength

10 mg

Quantity

30 Tablet/s, 60 Tablet/s, 90 Tablet/s

Pharma Form

Tablet/s

Manufacturer

Cipla Inc

Treatment

Migraine, Chest pain (Angina), High blood pressure

Generic Brand

Propranolol

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