Combigan Eye Drops

Product Overview

Combigan Eye Drop is a dual-action ophthalmic solution containing Brimonidine tartrate and Timolol as active ingredients. This advanced formulation provides comprehensive ocular therapy, specifically designed to manage elevated intraocular pressure effectively.

Therapeutic Indications

Combigan Eye Drop is clinically indicated for the treatment of open-angle glaucoma and ocular hypertension – conditions characterized by abnormally high pressure within the eye that may potentially damage the optic nerve if left untreated.

Mechanism of Action

The synergistic pharmacological effects of Combigan Eye Drop include:

• Brimonidine tartrate: As a selective alpha-2 adrenergic agonist, it decreases aqueous humor production while increasing uveoscleral outflow.
• Timolol: This non-selective beta-adrenergic receptor blocker reduces aqueous humor production through ciliary body inhibition.

This complementary action provides superior intraocular pressure reduction compared to monotherapy.

Recommended Dosage

For optimal therapeutic outcomes in glaucoma or ocular hypertension management:

• Instill one drop in the affected eye(s) twice daily, approximately 12 hours apart
• Maintain strict aseptic technique during administration
• Avoid contact between dropper tip and ocular surface or surrounding structures
• Wait at least 5 minutes between administering different eye medications

Therapeutic Advantages

Combigan Eye Drop offers significant clinical benefits:

1. Potent reduction of intraocular pressure (IOP) through dual mechanisms
2. Decreased risk of optic nerve damage and visual field loss
3. Enhanced patient compliance through simplified dosing regimen
4. Suitable for both initial therapy and adjunctive treatment

Adverse Effects

While generally well-tolerated, some patients may experience:

• Ocular hyperemia (redness)
• Ocular pruritus (itching)
• Visual disturbances
• Foreign body sensation
• Dry eye symptoms

Persistent or severe reactions require immediate medical evaluation.

Important Precautions

Before initiating therapy:

• Disclose complete medical history, including cardiovascular or respiratory conditions
• Inform physician about all concomitant medications
• Pregnant/lactating women should consult healthcare provider
• Remove contact lenses prior to instillation (wait 15 minutes before reinsertion)
• Monitor for systemic beta-blocker effects in susceptible patients

Storage Conditions

For product stability and efficacy:

• Store at controlled room temperature (2°C to 25°C)
• Protect from light and excessive heat
• Keep container tightly closed when not in use
• Discard 28 days after first opening
• Keep out of reach of children