Cozartan-H

Product Overview

Cozartan-H is a combination medication containing Losartan potassium and Hydrochlorothiazide as active ingredients. This dual-action formulation combines an angiotensin II receptor blocker (ARB) with a thiazide diuretic to effectively manage hypertension (high blood pressure). The synergistic action of these components targets multiple pathways to achieve optimal blood pressure control.

Therapeutic Indications

Cozartan-H is indicated for the treatment of hypertension in adult patients when single-agent therapy with either Losartan or Hydrochlorothiazide proves inadequate. The medication works through complementary mechanisms: Losartan potassium induces vasodilation by blocking angiotensin II receptors, while Hydrochlorothiazide promotes diuresis, reducing fluid volume and peripheral vascular resistance.

Administration Guidelines

Take Cozartan-H precisely as directed by your healthcare professional. The standard regimen involves oral administration of one tablet daily, with or without food. The tablet should be swallowed whole with water. Maintain consistent dosing times and do not modify your dosage without medical supervision.

Mechanism of Action

This combination therapy exerts its antihypertensive effects through dual pharmacological actions:
1. Losartan potassium selectively antagonizes angiotensin II receptors, preventing vasoconstriction
2. Hydrochlorothiazide inhibits sodium reabsorption in the distal convoluted tubule, promoting natriuresis and diuresis
This combined approach effectively reduces both vascular resistance and circulating blood volume.

Dosage Protocol

The dosage of Cozartan-H is individualized based on therapeutic response and tolerability. Initial therapy typically begins with:
– Losartan potassium 50 mg/Hydrochlorothiazide 12.5 mg once daily
Dosage may be titrated upward to:
– Losartan potassium 100 mg/Hydrochlorothiazide 25 mg once daily (maximum recommended dose)
Regular blood pressure monitoring is essential for optimal dose adjustment.

Therapeutic Advantages

Cozartan-H offers comprehensive cardiovascular protection by:
– Effectively lowering blood pressure
– Reducing hypertension-related complications
– Minimizing cardiovascular morbidity and mortality
– Providing convenient once-daily dosing
The fixed-dose combination enhances patient compliance while maintaining therapeutic efficacy.

Adverse Effects

Common adverse reactions may include:
– Dizziness
– Fatigue
– Headache
– Polyuria
– Orthostatic hypotension
These effects are typically mild and transient. Serious adverse effects (e.g., electrolyte disturbances, renal impairment, hypersensitivity reactions) require immediate medical attention.

Precautions and Contraindications

Exercise caution when prescribing Cozartan-H to patients with:
– Impaired renal/hepatic function
– Diabetes mellitus
– Gout
– Electrolyte abnormalities
Concomitant use with NSAIDs, lithium, or other antihypertensives may require dosage adjustment. Avoid use during pregnancy (second and third trimesters).

Storage Conditions

Maintain Cozartan-H at controlled room temperature (15-30°C) in original packaging. Protect from moisture and light. Keep out of reach of children. Properly dispose of expired medication.

Medical Disclaimer

This information serves educational purposes only and does not constitute medical advice. While we strive for accuracy, the content may not encompass all potential drug interactions, contraindications, or adverse effects. Always consult your healthcare provider for personalized medical guidance. This information supplements, but does not replace, professional medical judgment and the physician-patient relationship.