Duphalac Syrup

Product Overview

Duphalac Syrup is a lactulose-based medication that functions as an osmotic laxative. This synthetic sugar solution works by increasing water retention in the colon, resulting in stool softening and easier bowel movements. The syrup formulation is clinically proven for constipation relief and is approved for use across all age groups, from pediatric to geriatric patients.

Therapeutic Applications

As a first-line treatment for chronic constipation, Duphalac Syrup effectively regulates bowel function. Its secondary indication includes the management of hepatic encephalopathy, where it reduces ammonia absorption in patients with liver dysfunction. The syrup also serves as a bowel preparation agent for diagnostic procedures and surgical interventions.

Administration Guidelines

For optimal results, administer Duphalac Syrup orally during meals to minimize gastrointestinal discomfort. Precise dosing requires using the provided measuring device, as dosage varies by patient age, clinical condition, and therapeutic response. Proper hydration is essential during treatment to maintain electrolyte balance. Always shake the container vigorously before dispensing.

Mechanism of Action

The active component lactulose remains unabsorbed through the gastrointestinal tract until reaching the colon, where gut flora metabolize it into organic acids. This biochemical process creates an osmotic gradient that draws water into the intestinal lumen, increasing stool volume and decreasing transit time while normalizing bowel consistency.

Dosing Protocol

Adult constipation management typically initiates with 15-30 mL (1-2 tablespoons) daily, adjustable based on clinical response. Pediatric dosing follows weight-based calculations under medical supervision. For hepatic encephalopathy, dosing frequency may increase to 3-4 times daily. Strict adherence to prescribed regimens is crucial to avoid therapeutic complications.

Therapeutic Advantages

• Provides predictable relief from chronic constipation
• Demonstrates clinical efficacy in hepatic encephalopathy management
• Exhibits excellent safety profile for all patient demographics
• Offers convenient liquid formulation for precise dosing
• Serves as effective bowel preparation solution

Adverse Effects

Most patients tolerate Duphalac Syrup well, with transient flatulence, abdominal distension, and mild cramping being the most frequently reported effects. Diarrhea may occur with excessive dosing. Rare but serious reactions include electrolyte disturbances and hypersensitivity responses. Discontinue use and seek immediate medical attention for severe abdominal pain or allergic manifestations.

Precautions and Contraindications

Patients with diabetes mellitus, galactosemia, or intestinal obstruction require special consideration. Pregnancy and lactation status should be disclosed before initiation. Potential drug interactions necessitate comprehensive medication review. Chronic unsupervised use may lead to laxative dependence and should be avoided.

Storage Conditions

Maintain Duphalac Syrup at controlled room temperature (20-25°C) in its original container. Protect from moisture and direct sunlight. Ensure proper bottle closure after each use. Do not refrigerate or freeze. Dispose of expired or unused medication according to local pharmaceutical waste guidelines.

Medical Disclaimer:

The content provided represents carefully vetted medical information from authoritative sources. However, this material serves educational purposes only and should not replace professional clinical judgment. Healthcare providers must evaluate individual patient circumstances, as this information may not encompass all potential adverse effects, contraindications, or drug interactions. Always consult qualified medical professionals for personalized treatment recommendations. This resource aims to complement, not substitute, the essential physician-patient relationship.