Progesterone

Product Overview

Endogest is a progesterone-based medication containing Natural Micronized Progesterone as its active ingredient, presented in soft gelatin capsule form. This bioidentical hormone supplement replicates the physiological effects of endogenous progesterone. Designed to address multiple aspects of women’s health, Endogest offers therapeutic support for reproductive and hormonal functions.

Indications

Endogest is clinically indicated for managing various gynecological and hormonal conditions. Its primary applications include luteal phase support in assisted reproductive technologies (ART) like IVF, prevention of recurrent miscarriage in progesterone-deficient women, and treatment of menstrual irregularities. It also serves as hormone replacement therapy for menopausal symptoms and as a protective agent against endometrial hyperplasia in estrogen-treated patients.

Administration Guidelines

For optimal results, take Endogest capsules orally following your physician’s instructions. The capsules should be swallowed intact with sufficient water, ideally with meals to enhance absorption and reduce gastrointestinal discomfort. Strict adherence to prescribed dosing schedules is crucial. In case of a missed dose, take it promptly unless it’s nearly time for the next scheduled dose – never compensate by doubling the dose.

Mechanism of Action

The natural micronized progesterone in Endogest functions as a key reproductive hormone. It facilitates endometrial transformation for embryo implantation, maintains uterine quiescence during pregnancy, and modulates the hypothalamic-pituitary-ovarian axis. Beyond its reproductive effects, progesterone exerts neurosteroid activity that may contribute to mood stabilization and anxiolytic effects.

Dosage Protocol

Endogest dosing is individualized based on therapeutic indication and patient response. Typical regimens range from 200-400 mg daily, administered in single or divided doses. Treatment duration varies from short-term luteal support to extended menopausal therapy. Physicians may adjust dosages based on clinical response, serum progesterone levels, and tolerability profile.

Therapeutic Advantages

• Enhances endometrial receptivity and supports early pregnancy maintenance
• Corrects progesterone deficiency-related menstrual irregularities
• Provides effective relief from vasomotor and psychological menopausal symptoms
• Offers endometrial protection in estrogen replacement regimens
• Promotes hormonal equilibrium throughout the reproductive lifespan

Adverse Effects

The most frequently reported adverse reactions to Endogest include somnolence, mild dizziness, mastalgia, abdominal distension, and cephalgia. These typically represent transient adaptation responses that diminish with continued use. Persistent or bothersome symptoms should prompt medical consultation.

Precautions

Special consideration is required for patients with known hypersensitivity to progesterone or capsule excipients. Immediate discontinuation and emergency care are warranted if allergic manifestations (urticaria, angioedema, bronchospasm) occur. Caution is advised in patients with hepatic impairment or history of thromboembolic disorders.

Important Safety Information

Endogest is contraindicated in cases of undiagnosed vaginal bleeding, active thrombophlebitis, or hormone-sensitive malignancies. Pregnancy use requires strict medical supervision. Comprehensive medication reconciliation is essential before initiation to identify potential pharmacokinetic interactions or contraindications.

Storage Conditions

Maintain Endogest capsules at controlled room temperature (15-30°C) in their original packaging, protected from humidity and light exposure. Ensure secure storage away from pediatric access. Discard any expired medication properly, as degradation products may compromise efficacy and safety.

Medical Disclaimer

The information provided herein represents carefully vetted, evidence-based data intended for educational purposes only. This content does not constitute medical advice nor replace professional clinical judgment. Healthcare providers should be consulted for diagnosis, treatment decisions, and comprehensive risk-benefit assessments. This material may not encompass all potential adverse effects, contraindications, or drug interactions. Our aim is to facilitate informed patient-provider discussions, not to supersede them.