Glide

Product Overview

Glide is an oral antidiabetic medication containing Glipizide SR, a sustained-release formulation of the sulfonylurea class. This medication is specifically designed to help manage type 2 diabetes mellitus by stimulating pancreatic insulin secretion. The sustained-release technology ensures gradual medication absorption, providing consistent blood sugar control with convenient once-daily dosing.

Uses

Glide is prescribed for adults with type 2 diabetes when lifestyle modifications (diet and exercise) prove insufficient for glycemic control. As an insulin secretagogue, it enhances the pancreas’ ability to produce insulin, thereby improving glucose utilization by peripheral tissues. It may be administered as standalone therapy or combined with other glucose-lowering agents to achieve target HbA1c levels.

How to Use

Take Glide tablets whole with water during breakfast or your first main meal. The tablets must not be crushed, chewed, or divided to maintain their extended-release properties. Dosage is personalized based on glycemic response, typically starting at 5mg daily. Maintain your prescribed diet and exercise regimen while using this medication for optimal therapeutic outcomes.

How it Works

Glipizide SR exerts its hypoglycemic effect by binding to ATP-sensitive potassium channels on pancreatic β-cells. This interaction triggers calcium influx, stimulating insulin release proportional to glucose concentration. The sustained-release matrix gradually delivers glipizide over 24 hours, mimicking physiological insulin secretion patterns while minimizing peak-trough fluctuations.

Dosage and Administration

Initial therapy typically begins with 5mg once daily, with possible titration up to 20mg daily based on glycemic monitoring. Dose adjustments should occur at minimum 7-day intervals. Elderly patients or those with hepatic impairment may require lower starting doses. Regular blood glucose monitoring is crucial during therapy initiation and dosage modifications.

Benefits

1. Clinically proven efficacy in type 2 diabetes management
2. Maintains stable postprandial and fasting glucose levels
3. Extended-release formulation ensures 24-hour coverage
4. Glucose-dependent insulin secretion reduces hypoglycemia risk
5. Flexible as monotherapy or combination treatment

Common Side Effects

The most frequently reported adverse effects include mild hypoglycemia (especially during dose escalation), transient gastrointestinal symptoms (nausea, epigastric fullness), and headache. These typically resolve with continued therapy. Patients should maintain regular meal patterns and carry glucose tablets to manage potential hypoglycemic episodes.

Warnings

Contraindicated in type 1 diabetes, diabetic ketoacidosis, and severe hepatic/renal impairment. Use caution in elderly patients, those with G6PD deficiency, or during concurrent use of beta-blockers. Periodic liver function tests are recommended. Discontinue if jaundice occurs. May cause photosensitivity – use sun protection during therapy.

Storage Information

Store below 25°C (77°F) in original packaging, protected from moisture and light. Avoid bathroom storage due to humidity fluctuations. Keep blister strips intact until administration. Properly dispose of expired medication and keep all pharmaceuticals out of children’s reach.

Disclaimer:

This information is provided for educational purposes only and does not constitute medical advice. While we strive for accuracy, this content may not encompass all potential drug interactions, contraindications, or adverse effects. Always consult your healthcare provider before initiating or modifying any treatment regimen. This material supports but does not replace professional medical judgment. Individual patient requirements may vary based on comprehensive clinical evaluation.