Great-Od

Product Overview

GR8-OD is a dual-action medication combining Pantoprazole (a proton pump inhibitor) and Domperidone (a dopamine antagonist). This pharmaceutical formulation is specifically designed to address gastrointestinal disorders by simultaneously reducing gastric acid secretion and enhancing digestive motility. The tablet formulation provides comprehensive relief for conditions including acid reflux, gastritis, and functional dyspepsia through its synergistic mechanism of action.

Therapeutic Indications

This medication is clinically indicated for:
– Gastroesophageal reflux disease (GERD)
– Erosive gastritis
– Peptic ulcer disease
– Functional dyspepsia
– Delayed gastric emptying

GR8-OD effectively manages symptoms including pyrosis, acid regurgitation, epigastric discomfort, postprandial fullness, and nausea through its dual pharmacological activity.

Administration Guidelines

For optimal therapeutic outcomes:
1. Take one tablet orally once daily
2. Administer before breakfast (preferably 30 minutes prior)
3. Swallow whole with 200mL water
4. Maintain consistent dosing schedule
5. Avoid crushing or chewing tablets

Note: Dosage adjustments should only be made under medical supervision. Maximum daily intake should not exceed one tablet unless specifically prescribed.

Mechanism of Action

GR8-OD exerts its therapeutic effects through:
1. Pantoprazole component:
– Irreversibly inhibits H+/K+-ATPase proton pumps
– Suppresses basal and stimulated acid secretion
– Creates prolonged antisecretory effect (>24 hours)

2. Domperidone component:
– Blocks peripheral dopamine D2 receptors
– Enhances gastroduodenal motility
– Accelerates gastric emptying
– Increases lower esophageal sphincter tone

Posology

Standard dosage regimen:
– Adults: 1 tablet (Pantoprazole 40mg + Domperidone 30mg) OD
– Geriatric patients: Requires renal function assessment
– Hepatic impairment: Dose adjustment necessary
– Duration: Typically 4-8 weeks (maintenance therapy may be considered)

Therapeutic Advantages

GR8-OD offers comprehensive gastrointestinal management by:
– Providing rapid and sustained acid suppression
– Improving upper GI motility
– Reducing reflux episodes
– Enhancing treatment compliance through simplified dosing
– Minimizing polypharmacy in comorbid conditions

Adverse Effects

Common adverse reactions (incidence >1%):
– Gastrointestinal: Diarrhea, abdominal pain, flatulence
– Neurological: Headache, dizziness
– General: Fatigue

Serious but rare effects requiring medical attention:
– QT prolongation
– Extrapyramidal symptoms
– Hypomagnesemia (with prolonged use)
– Clostridium difficile-associated diarrhea

Precautions and Contraindications

Absolute contraindications:
– Known hypersensitivity to components
– Concomitant use with QT-prolonging drugs
– Prolactin-releasing pituitary tumors

Special precautions:
– Cardiac evaluation recommended in high-risk patients
– Long-term therapy requires periodic magnesium monitoring
– May interfere with absorption of vitamin B12 and iron

Storage Conditions

Maintain product integrity by:
– Storing below 30°C
– Protecting from moisture
– Keeping in original blister packaging
– Ensuring proper disposal of expired medication

Medical Disclaimer

This information serves educational purposes only and does not constitute medical advice. While we strive for accuracy, healthcare decisions should always be made in consultation with qualified medical professionals. The complete prescribing information includes additional details on warnings, drug interactions, and special populations not fully covered herein. Patients are advised to disclose their full medical history and current medications to their healthcare provider before initiating therapy.