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Product Overview

Hyloric is a pharmaceutical formulation containing Allopurinol as its active ingredient, presented in tablet dosage form. This medication is extensively prescribed for the management of gout and related disorders characterized by elevated serum uric acid concentrations. Allopurinol functions by inhibiting uric acid synthesis, thereby preventing the deposition of urate crystals in articular joints and renal tissue, which are responsible for gouty arthritis and nephrolithiasis respectively.

Therapeutic Indications

Hyloric tablets are principally indicated for:

• Treatment and prophylaxis of gouty arthritis
• Management of uric acid nephrolithiasis
• Control of hyperuricemia secondary to chemotherapy

This medication is particularly valuable for patients experiencing recurrent gout episodes or those susceptible to complications arising from persistent hyperuricemia.

Administration Guidelines

For optimal therapeutic outcomes:

• Administer orally with 200-250mL of water
• Preferably consume postprandially to mitigate gastrointestinal irritation
• Maintain strict adherence to prescribed dosing regimen
• Swallow tablets intact – do not crush, chew, or divide

Mechanism of Action

Allopurinol exerts its pharmacological effect through competitive inhibition of xanthine oxidase, the rate-limiting enzyme in uric acid biosynthesis. This inhibition results in:

• Reduced serum urate concentrations
• Decreased urate crystal formation
• Prevention of acute gout flares
• Inhibition of uric acid calculi development

Dosage Protocol

Standard dosing recommendations:

Indication	Initial Dose	Maintenance Dose
Gout	100mg daily	100-300mg daily
Hyperuricemia	100-200mg daily	200-600mg daily

Note: Dosage must be individualized based on renal function and therapeutic response.

Therapeutic Advantages

• Proven efficacy in acute and chronic gout management
• Significant reduction in tophaceous deposits
• Prevention of uric acid nephropathy
• Decreased frequency of arthritic flares
• Improved patient mobility and quality of life

Adverse Effects

Frequently reported undesirable effects include:

• Gastrointestinal disturbances (nausea, diarrhea)
• Transient cutaneous eruptions
• Mild cephalalgia
• Hepatic enzyme elevation

Most adverse reactions are self-limiting and diminish with continued therapy.

Precautions

Special considerations:

• Monitor hepatic function periodically
• Maintain adequate hydration (2-3L daily)
• Assess renal function before initiation
• Caution in patients with HLA-B*5801 allele

Contraindications

Hyloric is contraindicated in:

• Hypersensitivity to allopurinol or excipients
• Concurrent use with azathioprine or mercaptopurine
• Severe hepatic impairment
• Acute gout attacks (initiation phase)

Storage Conditions

Optimal storage parameters:

• Temperature: 15-30°C
• Protect from moisture and light
• Maintain in original packaging
• Keep out of pediatric reach

Medical Disclaimer

The information provided herein represents carefully curated, evidence-based data that has undergone rigorous medical review. However, this content:

• Does not constitute medical advice
• Should not replace professional clinical judgment
• May not encompass all potential adverse effects
• Does not account for individual patient variability

Patients are strongly advised to consult qualified healthcare providers for personalized medical guidance. This information serves as an educational supplement to, not a substitute for, the physician-patient relationship.