Indicid-75 SR

Product Overview

Indicid-75 SR is a sustained-release formulation containing Indomethacin as its active pharmaceutical ingredient. As a nonsteroidal anti-inflammatory drug (NSAID), it is clinically indicated for managing inflammatory disorders such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis. The medication exerts its therapeutic effects by selectively inhibiting prostaglandin synthesis, thereby reducing inflammation, pain, and fever associated with these conditions.

Therapeutic Indications

This pharmaceutical preparation is specifically designed to alleviate pain, inflammation, and swelling in various musculoskeletal disorders. Its primary clinical applications include:
• Rheumatoid arthritis management
• Osteoarthritis treatment
• Ankylosing spondylitis therapy
• Acute gouty arthritis resolution
The sustained-release formulation provides prolonged therapeutic action while maintaining optimal plasma concentrations.

Administration Guidelines

For optimal therapeutic outcomes:
1. Administer orally with 240 mL of water
2. Preferably consume with meals or dairy products to mitigate gastric irritation
3. Swallow tablets intact – do not crush, chew, or divide
4. Maintain regular dosing intervals as prescribed
5. If a dose is missed, administer promptly unless approaching the next scheduled dose

Mechanism of Action

Indicid-75 SR pharmacodynamically functions through:
• Competitive inhibition of cyclooxygenase (COX) enzymes
• Subsequent reduction in prostaglandin biosynthesis
• Modulation of inflammatory mediators
• Attenuation of pain perception pathways
This dual COX-1/COX-2 inhibition results in comprehensive anti-inflammatory, analgesic, and antipyretic effects.

Dosage Protocol

Standard dosing recommendations:
• Initial adult dosage: 75 mg once daily
• Maximum daily dose: 200 mg (divided administration)
• Geriatric adjustment: Consider reduced initial dosing
• Hepatic/Renal impairment: Require dosage modification
Note: Therapeutic response should be evaluated periodically, with dosage adjustments made under medical supervision.

Therapeutic Advantages

Clinical benefits include:
• Sustained anti-inflammatory action
• Improved joint mobility and function
• Reduced arthritic pain and stiffness
• Prevention of progressive joint degeneration
• Effective management of acute gout flares
The modified-release formulation enhances patient compliance through simplified dosing regimens.

Adverse Effect Profile

Commonly reported adverse reactions:
• Gastrointestinal: Dyspepsia (10-15%), epigastric pain (5-8%)
• Central Nervous System: Cephalgia (3-5%), vertigo (2-4%)
• Cardiovascular: Peripheral edema (1-3%), hypertension (1-2%)
• Dermatological: Pruritus (1-2%), rash (0.5-1%)
Monitoring for serious gastrointestinal events is recommended, particularly in high-risk populations.

Precautions and Contraindications

Special warnings include:
• Absolute contraindication in NSAID hypersensitivity
• Caution required in:
– Elderly patients (≥65 years)
– Cardiovascular comorbidities
– Impaired renal/hepatic function
– History of peptic ulcer disease
• Boxed warning for increased cardiovascular thrombotic risk
Concomitant use with other NSAIDs or anticoagulants requires careful risk-benefit assessment.

Storage Conditions

Proper storage parameters:
• Temperature: 20-25°C (68-77°F)
• Protection from:
– Moisture (keep in original container)
– Direct sunlight
– Excessive heat
• Shelf life: 24 months from manufacturing date
Dispose of expired medication through authorized pharmaceutical waste channels.

Medical Disclaimer

The information provided herein represents current pharmacological knowledge but does not constitute medical advice. This monograph:
• Is intended for healthcare professionals
• Should not replace clinical judgment
• May not include all potential drug interactions
• Does not account for individual patient variables
Always consult qualified medical personnel for personalized therapeutic recommendations. This content aims to supplement, not supersede, the physician-patient relationship.