Ibuprofen-R

Product Overview

Inmecin-R is a sustained-release NSAID medication containing Indomethacin. This specialized formulation gradually releases the active ingredient over time, enabling once-daily dosing for effective management of pain, inflammation, and fever associated with arthritis, gout, and specific headache types. By blocking prostaglandin production, it addresses the root causes of inflammatory symptoms.

Uses

Inmecin-R is clinically indicated for:
– Rheumatoid arthritis and osteoarthritis management
– Ankylosing spondylitis treatment
– Acute gout attacks
– Shoulder pain from bursitis/tendinitis
– Tension headaches and migraines
– Fever reduction in febrile conditions

How to Use

Administration Guidelines:
1. Take with 8oz water during meals
2. Swallow capsules intact (do not crush/chew)
3. Follow prescribed dosing schedule
4. Maintain consistent timing for optimal results
5. Report any swallowing difficulties immediately

How it Works

Mechanism of Action:
Inmecin-R’s sustained-release indomethacin selectively inhibits COX enzymes, disrupting prostaglandin synthesis. This pharmacological action produces a triple therapeutic effect:
1. Anti-inflammatory (reduces swelling)
2. Analgesic (relieves pain)
3. Antipyretic (lowers fever)

Dosage and Administration

Standard Protocol:
• Initial dose: 75mg once daily
• Maintenance range: 75-150mg/day
• Maximum: 200mg/day (divided doses)
Special Populations:
– Elderly: Start with 50% normal dose
– Renal impairment: Reduced frequency
– Hepatic dysfunction: Monitor closely

Benefits

Therapeutic Advantages:

1. 24-hour symptom control with single dosing
2. Reduced GI irritation vs immediate-release forms
3. Comprehensive inflammatory pathway targeting
4. Proven efficacy across multiple indications
5. Improved medication adherence

Common Side Effects

Frequency >1%:
• GI: Nausea (12%), dyspepsia (9%), diarrhea (5%)
• CNS: Headache (7%), dizziness (4%)
• Dermatologic: Rash (3%)
• Cardiovascular: Edema (2%)

Warnings

Important Safety Information:
BOXED WARNING: Cardiovascular/thrombotic risk
Contraindications:
– NSAID hypersensitivity
– Aspirin triad history
– Perioperative CABG pain
Precautions:
• GI ulcer monitoring required
• Renal function tests recommended
• Blood pressure monitoring advised
• Avoid concurrent anticoagulants

Storage Information

Proper Handling:
✓ Store at 20-25°C (68-77°F)
✓ Protect from humidity
✓ Keep in original packaging
✓ Check expiration dating
✗ Do not transfer to pill organizers

Disclaimer:

This information serves educational purposes only and does not constitute medical advice. While we strive for accuracy, pharmaceutical knowledge evolves continuously. Always:
– Consult your prescribing physician
– Review current FDA labeling
– Report adverse events promptly
– Disclose all concomitant medications
Remember: Proper diagnosis precedes appropriate treatment.