Losatec H

Product Overview

Losatec H is a combination medication containing Losartan Potassium and Hydrochlorothiazide as active ingredients. Losartan functions as an angiotensin II receptor blocker, while Hydrochlorothiazide acts as a thiazide diuretic. This dual-action formulation effectively treats hypertension by simultaneously relaxing blood vessels and promoting diuresis to reduce fluid volume. Available in tablet form for oral administration, Losatec H provides a comprehensive approach to blood pressure management.

Therapeutic Indications

This medication is indicated for the treatment of essential hypertension in adults. The combination therapy is particularly beneficial when monotherapy proves inadequate, offering enhanced blood pressure reduction through complementary mechanisms. By effectively controlling hypertension, Losatec H helps mitigate cardiovascular risks including myocardial infarction and cerebrovascular accidents.

Administration Guidelines

The tablets should be swallowed whole with water, with or without food, as prescribed. Consistency in daily dosing time is recommended to maintain therapeutic levels. If a dose is missed, it should be taken upon recollection unless approaching the next scheduled dose. Dose doubling is strictly contraindicated. Patients should maintain adequate hydration unless otherwise advised by their physician.

Mechanism of Action

Losartan selectively blocks AT1 receptors, inhibiting angiotensin II-mediated vasoconstriction and aldosterone secretion, resulting in vasodilation. Hydrochlorothiazide inhibits sodium-chloride symport in the distal convoluted tubule, increasing excretion of sodium, chloride, and water. This synergistic action produces greater antihypertensive effects than either component alone.

Dosage Protocol

Standard initiation involves one tablet (typically containing 50mg Losartan/12.5mg HCTZ) once daily. Dosage adjustments should be made at 2-4 week intervals based on therapeutic response and tolerability, not exceeding maximum recommended doses. Renal function and electrolyte levels should be monitored periodically during therapy.

Therapeutic Advantages

Key benefits include:
– Dual mechanism for enhanced efficacy
– Simplified dosing regimen
– Potential renal protective effects (Losartan component)
– Reduced cardiovascular risk profile
– Favorable tolerability compared to higher-dose monotherapy

Adverse Effects

Frequently reported reactions include:
– Orthostatic hypotension (particularly during initial therapy)
– Mild electrolyte disturbances
– Transient dizziness
– Headache
– Gastrointestinal discomfort
These typically resolve with continued treatment. Persistent or severe reactions warrant medical evaluation.

Precautions

Special consideration is required for:
– Patients with renal impairment (CrCl <30mL/min) - Hepatic dysfunction - Electrolyte abnormalities - Gout predisposition - Concomitant NSAID or lithium use - Pregnancy (contraindicated in second/third trimester) Storage Conditions

Maintain at controlled room temperature (15-30°C) in original packaging. Protect from moisture and light. Keep securely closed and out of reach of children. Dispose of expired medication through authorized take-back programs.

Medical Disclaimer

This information serves educational purposes only and does not constitute medical advice. While we strive for accuracy, this content may not encompass all potential interactions, contraindications, or adverse effects. Always consult a qualified healthcare professional regarding any medical condition or treatment. This information supplements but does not replace professional medical judgment or the physician-patient relationship.