Meloset (Melatonin)

Product Overview

Meloset is a pharmaceutical formulation containing Melatonin as its active ingredient, available in tablet form. Melatonin is a naturally occurring hormone secreted by the pineal gland that plays a crucial role in regulating circadian rhythms. These tablets are designed to supplement endogenous melatonin levels, effectively addressing sleep initiation and maintenance difficulties while promoting restorative sleep patterns.

Therapeutic Indications

Meloset tablets are indicated for:
– Management of insomnia and sleep onset disorders
– Circadian rhythm synchronization in jet lag and shift work sleep disorder
– Treatment of delayed sleep phase syndrome
The active component facilitates sleep induction by mimicking the body’s natural sleep-wake regulation mechanisms.

Administration Guidelines

For optimal efficacy:
– Administer orally 30-60 minutes prior to desired sleep time
– Consume with water (avoid concurrent high-fat meals)
– Swallow tablets whole; do not crush or chew
– Adhere strictly to prescribed dosing regimen

Mechanism of Action

Meloset exerts its therapeutic effects through:
1. Binding to MT1 and MT2 receptors in the suprachiasmatic nucleus
2. Phase-shifting circadian rhythms to align with desired sleep periods
3. Reducing sleep latency through GABAergic modulation
4. Enhancing sleep efficiency and total sleep time

Dosage Protocol

Standard dosing recommendations:
– Adults: 3-5 mg once daily at bedtime
– Geriatric patients: Initiate with 1-2 mg, titrate as needed
– Special populations: Adjust based on hepatic function and therapeutic response

Note: Individualized dosing under medical supervision is essential for optimal outcomes.

Therapeutic Advantages

• Facilitates physiological sleep architecture
• Addresses both sleep initiation and maintenance difficulties
• Minimal next-day residual effects compared to conventional hypnotics
• Non-habit forming with proper use
• Improves sleep quality metrics (sleep efficiency, WASO reduction)

Adverse Effect Profile

Common treatment-emergent effects (typically mild and self-limiting):
– Somnolence (15-20%)
– Cephalgia (5-8%)
– Vertigo (3-5%)
– Gastrointestinal discomfort (2-4%)
– Daytime sedation (dose-dependent)

Important Considerations

Clinical precautions include:
– Potential pharmacodynamic interactions with CNS depressants
– Caution in patients with autoimmune conditions
– Possible exacerbation of depressive symptoms
– Requires careful monitoring in hepatic impairment
– Contraindicated in pregnancy/lactation

Safety Warnings

Absolute contraindications:
– Hypersensitivity to melatonin or excipients
– Autoimmune disease patients
– Severe hepatic insufficiency

Relative contraindications:
– Epilepsy
– Immunocompromised status
– Concurrent anticoagulant therapy

Storage Specifications

Optimal storage conditions:
– Temperature: 15-30°C
– Humidity: <60% RH - Protection from light exposure - Original packaging retention - Secure storage away from pediatric access Medical Disclaimer:

The information provided herein represents comprehensive pharmaceutical data intended for healthcare professionals. This content should not substitute for personalized medical advice. While we strive for accuracy, prescribing decisions should be based on individual patient characteristics and professional clinical judgment. Consult your healthcare provider for specific therapeutic recommendations and to address any concerns regarding potential drug interactions or contraindications. This information supports but does not replace the essential physician-patient relationship.