Metopar

Product Overview

Metopar is a combination medication containing Paracetamol (an analgesic and antipyretic) and metoclopramide (an antiemetic agent). This dual-action formulation effectively addresses pain, fever, and associated nausea/vomiting. The medication is particularly beneficial for managing headache, musculoskeletal pain, dental discomfort, dysmenorrhea, and nausea related to migraines or delayed gastric emptying.

Therapeutic Indications

This medication is indicated for:
• Symptomatic treatment of mild-to-moderate pain (including cephalalgia, myalgia, odontalgia, and menstrual cramps)
• Fever reduction
• Management of nausea and vomiting associated with:
– Migraine episodes
– Chemotherapy-induced emesis
– Gastroparesis
The metoclopramide component enhances gastric motility while providing antiemetic effects.

Administration Guidelines

For optimal results:
1. Take orally with 200-250mL water
2. Swallow tablets whole (do not crush/chew)
3. Adhere to prescribed dosing schedule
4. Maintain adequate hydration
5. Avoid concomitant alcohol consumption

Mechanism of Action

• Paracetamol: Inhibits cyclooxygenase pathways in the CNS, reducing prostaglandin-mediated pain and fever responses
• Metoclopramide:
– Dopamine D2 receptor antagonism (chemoreceptor trigger zone)
– 5-HT4 receptor agonism (enhances gastric motility)
– 5-HT3 receptor antagonism (anti-emetic effect)

Dosage Protocol

Standard dosing (adults ≥16 years):
• 1-2 tablets every 4-6 hours (maximum 8 tablets/24h)
• Maximum daily paracetamol: 4g
• Maximum treatment duration:
– Analgesia: 5 days
– Antipyresis: 3 days
Pediatric dosing requires medical supervision. Hepatic/renal impairment necessitates dose adjustment.

Therapeutic Advantages

Key benefits include:
✓ Synergistic pain-nausea control
✓ Rapid onset of action (30-60 minutes)
✓ Convenient oral formulation
✓ Suitable for acute symptomatic management
✓ Cost-effective combination therapy

Adverse Effects

Frequently observed (≥1/100):
• Somnolence
• Mild dizziness
• Transient headache
• Gastrointestinal discomfort
Serious reactions requiring immediate medical attention:
• Hepatotoxicity (right upper quadrant pain, jaundice)
• Extrapyramidal symptoms
• Cardiac arrhythmias
• Severe cutaneous reactions

Precautions and Contraindications

Absolute contraindications:
• Known hypersensitivity to components
• Pheochromocytoma
• GI obstruction/perforation
• Parkinson’s disease
Special precautions for:
• Elderly patients
• Hepatic impairment
• Epilepsy history
• Concurrent CNS depressants

Storage Conditions

• Temperature: 15-30°C
• Humidity: <60% RH • Light protection: Required • Keep in original packaging • Shelf life: Refer to expiration dating • Disposal: Follow local pharmaceutical waste protocols

Medical Disclaimer

The information provided is for educational purposes only and does not constitute medical advice. While we strive for accuracy, this content:
– Is not exhaustive
– May not reflect current guidelines
– Should not replace professional consultation
Always consult your healthcare provider regarding:
✓ Appropriate use
✓ Potential interactions
✓ Individual risk assessment
✓ Therapeutic alternatives