This medication serves as prophylactic treatment to prevent postoperative infections and is also indicated for dental infections, chronic leg ulcers, and decubitus ulcers. For optimal absorption, administer with meals and maintain consistent dosing times. Dosage varies based on infection type and severity – strictly adhere to your physician’s prescribed regimen. Continue the full course even after symptom resolution to ensure complete eradication of pathogens and prevent antibiotic resistance. Avoid alcohol consumption during treatment and for 72 hours post-treatment to prevent disulfiram-like reactions including gastrointestinal distress.
Common adverse effects include cephalalgia, xerostomia, nausea, and dysgeusia (metallic taste). These typically resolve spontaneously but consult your healthcare provider if persistent. Sugar-free lozenges may alleviate oral discomfort.
Contraindications include hypersensitivity to nitroimidazole derivatives. Exercise caution in patients with hepatic/renal impairment or neurological disorders. Pregnancy and lactation status should be discussed with your physician prior to initiation.
THERAPEUTIC INDICATIONS
- Gram-positive and gram-negative bacterial infections
- Protozoal and anaerobic infections
CLINICAL BENEFITS
Antimicrobial Efficacy
The bactericidal mechanism involves inhibition of nucleic acid synthesis through free radical-mediated DNA strand breakage. While symptomatic improvement often occurs rapidly, complete the prescribed course to prevent development of resistant strains. Teratogenic risk should be evaluated in pregnancy; excretion in breast milk necessitates medical consultation.
ADVERSE EFFECTS
Frequently Reported Reactions
- Cephalalgia
- Xerostomia
- Emesis
- Parageusia
ADMINISTRATION GUIDELINES
PHARMACODYNAMICS
Medical Disclaimer:
The content provided is intended for educational purposes only and represents curated medical information verified by healthcare professionals. This information should not substitute professional medical advice, diagnosis, or treatment. The complete profile of adverse effects, contraindications, and drug interactions may not be fully enumerated herein. Always consult your healthcare provider regarding any medical condition or therapeutic regimen. This resource aims to facilitate informed patient-provider discussions, not replace clinical judgment.
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