Nicol

Product Overview

Nilol is a combination medication containing Nifedipine and Atenolol as active ingredients. This dual-action formulation effectively manages hypertension (high blood pressure) and angina (chest pain) by combining the benefits of a calcium channel blocker (Nifedipine) with a beta-blocker (Atenolol). The synergistic action helps regulate blood pressure while reducing cardiac workload, thereby improving coronary blood flow and myocardial oxygen supply.

Therapeutic Uses

Nilol is indicated for:
• Treatment of essential hypertension
• Management of chronic stable angina
• Prevention of angina episodes
The medication achieves these therapeutic effects through vasodilation and reduced myocardial oxygen demand. Healthcare providers may also prescribe Nilol for other cardiovascular indications based on clinical judgment.

Administration Guidelines

For optimal results:
• Take exactly as prescribed by your physician
• May be administered with or without food
• Swallow tablets whole with water (do not crush or chew)
• Maintain consistent dosing schedule
• Never discontinue abruptly without medical supervision
Dosage frequency typically ranges from once to twice daily, depending on individual patient requirements.

Mechanism of Action

The dual mechanism involves:
1. Nifedipine (Calcium Channel Blocker):
– Inhibits calcium ion influx
– Causes vascular smooth muscle relaxation
– Reduces peripheral vascular resistance

2. Atenolol (Beta-1 Selective Blocker):
– Competitively blocks beta-adrenergic receptors
– Decreases heart rate and contractility
– Lowers myocardial oxygen consumption

Dosage Protocol

Dosing is patient-specific and requires medical supervision:
• Hypertension: Initial dose typically 1 tablet daily (adjust based on response)
• Angina: Dosage varies according to symptom control
• Elderly/Hepatic Impairment: May require dose adjustment
Regular monitoring is essential during therapy initiation and dose titration.

Therapeutic Advantages

Clinical benefits include:
✓ Effective blood pressure control
✓ Reduced cardiovascular risk
✓ Improved exercise tolerance
✓ Decreased angina frequency
✓ Enhanced quality of life
The combination therapy often shows better efficacy than monotherapy with fewer side effects.

Adverse Effects

Commonly reported reactions:
• Central Nervous System: Dizziness, headache, fatigue
• Gastrointestinal: Nausea, constipation
• Cardiovascular: Peripheral edema, bradycardia
• Other: Cold extremities
Most effects are transient and dose-dependent. Report persistent or severe reactions immediately.

Important Precautions

Special considerations:
• Contraindicated in acute heart failure, cardiogenic shock
• Caution in patients with:
– Severe hepatic impairment
– Peripheral vascular disease
– Diabetes mellitus
• May mask hypoglycemia symptoms
• Requires gradual withdrawal
• Monitor renal function in impaired patients

Storage Conditions

Proper storage guidelines:
• Store at 15-30°C
• Protect from moisture and light
• Keep in original packaging
• Store away from children’s reach
• Do not use beyond expiration date
Dispose of unused medication properly according to local regulations.

Medical Disclaimer

The information provided is for educational purposes only and does not constitute medical advice. While we strive for accuracy, this content:
– Is not exhaustive
– May not reflect recent developments
– Should not replace professional consultation
Always consult your healthcare provider for:
✓ Diagnosis and treatment decisions
✓ Potential drug interactions
✓ Individualized medical advice
✓ Management of adverse effects
This information supports but does not replace the physician-patient relationship.