Nitroderm TTS

Product Overview

Nitroderm TTS is a transdermal therapeutic system (TTS) containing nitroglycerin as its active ingredient. This innovative patch delivers controlled doses of medication through the skin directly into the bloodstream. Primarily prescribed for coronary artery disease patients, Nitroderm TTS effectively prevents and relieves angina (chest pain) through its convenient, sustained-release delivery mechanism.

Uses

This medication is indicated for angina pectoris treatment – a condition marked by chest discomfort resulting from reduced cardiac blood flow. Nitroderm TTS works by vasodilation: expanding blood vessels to enhance coronary circulation, decrease cardiac workload, and prevent angina episodes while alleviating existing symptoms.

How to Use

For optimal results:
1. Clean and dry the application site (chest or upper arm)
2. Remove the protective backing
3. Firmly apply the patch to hair-free skin
4. Rotate application sites to prevent irritation
5. Wear continuously for 12-14 hours followed by a 10-12 hour patch-free period
Always follow your healthcare provider’s specific instructions regarding application and removal.

How it Works

Nitroderm TTS contains nitroglycerin, a potent vasodilator that primarily affects venous circulation. By relaxing blood vessel walls, it:
• Reduces venous return to the heart
• Lowers blood pressure
• Decreases cardiac workload
• Improves myocardial oxygenation
This dual action (increasing oxygen supply while reducing demand) effectively manages angina symptoms.

Dosage and Administration

Dosing is individualized based on:
• Angina severity
• Therapeutic response
• Tolerance development
Standard initiation begins with one 5mg patch daily. Your physician may adjust dosage for optimal symptom control while minimizing adverse effects. Strict adherence to prescribed regimens is crucial to prevent tolerance and rebound angina.

Benefits

Nitroderm TTS offers significant advantages:
• Continuous, controlled drug delivery
• Consistent symptom relief
• Reduced dosing frequency
• Improved treatment compliance
• Enhanced exercise capacity
• Better quality of life for angina patients

Common Side Effects

Most frequently reported reactions include:
• Headaches (most common)
• Application site reactions (redness, itching)
• Dizziness
• Facial flushing
• Hypotension
• Tachycardia
These typically resolve with continued use or patch removal. Seek medical attention for severe or persistent reactions.

Warnings

Special precautions apply for patients with:
• Hypotension
• Severe anemia
• Hypovolemia
• Recent MI/stroke
• Heart failure
Critical interactions occur with PDE-5 inhibitors (e.g., sildenafil), potentially causing dangerous hypotension. Never discontinue abruptly due to rebound angina risk. Close medical supervision is essential for high-risk patients.

Storage Information

Proper storage conditions:
• Room temperature (20°C-25°C/68°F-77°F)
• Original sealed packaging
• Dry environment away from heat/moisture
• Out of children’s/pets’ reach
• Never refrigerate or freeze
Always check expiration dates and properly dispose of expired patches.

Disclaimer:

This information has been medically reviewed for accuracy but should not replace professional medical advice. The content is for educational purposes only and may not encompass all potential side effects, interactions, or contraindications. Always consult your physician regarding health conditions and treatments. Our goal is to supplement, not substitute, the crucial doctor-patient relationship.