Nucoxia SP

Product Overview

Nucoxia SP is a combination medication formulated with Etoricoxib (60mg) and Serratiopeptidase (10mg) as active ingredients. Presented in tablet form, this medication combines the anti-inflammatory properties of Etoricoxib, a selective COX-2 inhibitor NSAID, with the proteolytic enzyme Serratiopeptidase which aids in reducing swelling and promoting tissue repair. This dual-action formulation effectively addresses pain and inflammation associated with various medical conditions.

Therapeutic Applications

This medication is primarily indicated for:

• Management of chronic inflammatory conditions including osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
• Acute gouty arthritis treatment
• Post-operative pain management
• Relief from musculoskeletal injuries such as sprains and strains

The Serratiopeptidase component enhances therapeutic efficacy by facilitating inflammatory protein breakdown and accelerating tissue recovery.

Administration Guidelines

For optimal results:

• Administer orally with sufficient water
• Preferably take with meals to minimize gastric irritation
• Swallow tablets whole without crushing or chewing
• Adhere strictly to prescribed dosage and treatment duration

Self-medication or dosage adjustment without medical supervision is strongly discouraged.

Mechanism of Action

The therapeutic effect is achieved through:

• Etoricoxib: Selective inhibition of cyclooxygenase-2 (COX-2) enzyme, thereby reducing prostaglandin synthesis responsible for pain and inflammation
• Serratiopeptidase: Proteolytic action that degrades inflammatory mediators and facilitates tissue repair processes

This synergistic action provides comprehensive anti-inflammatory and analgesic effects.

Dosage Protocol

Standard dosing recommendations:

• Adult dosage: Typically one tablet daily
• Maximum duration: As prescribed by treating physician
• Special populations: Dosage adjustments may be required for elderly patients or those with hepatic/renal impairment

Therapeutic response should be regularly evaluated to determine optimal treatment duration.

Therapeutic Advantages

Key benefits include:

• Effective dual-action pain and inflammation management
• Improved functional mobility in arthritic conditions
• Favorable gastrointestinal tolerability profile compared to conventional NSAIDs
• Convenient once-daily dosing schedule
• Enhanced tissue healing through enzymatic action

Adverse Effects

Commonly reported side effects (typically mild and transient):

• Gastrointestinal: Dyspepsia, epigastric discomfort, nausea
• CNS-related: Headache, dizziness
• Other: Mild edema, fatigue

Persistent or severe adverse reactions warrant immediate medical attention.

Precautions and Contraindications

Important safety considerations:

• Contraindicated in patients with active peptic ulcer disease or severe hepatic impairment
• Caution required in cardiovascular disease patients due to potential thromboembolic risk
• Not recommended during third trimester of pregnancy
• Avoid concurrent use with other NSAIDs or anticoagulants
• Alcohol consumption may exacerbate gastrointestinal adverse effects

Complete medical history disclosure to prescribing physician is essential.

Storage Requirements

Proper storage conditions:

• Temperature: Maintain at 15-30°C
• Protect from moisture and direct sunlight
• Keep in original packaging
• Store in secure location inaccessible to children

Properly dispose of expired medication according to local regulations.

Medical Disclaimer

The information provided herein is for educational purposes only and should not replace professional medical advice. While we strive for accuracy, this content may not encompass all potential drug interactions, contraindications, or adverse effects. Healthcare providers should be consulted for personalized medical guidance. This information is intended to complement, not substitute, the physician-patient relationship. Always follow your healthcare provider’s instructions regarding medication use.