Omez D

Product Overview

Omez D SR is a dual-action medication combining Omeprazole and Domperidone in capsule form. This specialized sustained-release formulation is designed to address gastrointestinal discomfort effectively. Omeprazole, a proton pump inhibitor (PPI), works to decrease gastric acid secretion, while Domperidone enhances digestive motility. Their combined action provides comprehensive relief from acid-related digestive disorders and associated symptoms.

Therapeutic Applications

This medication is primarily indicated for:
– Gastroesophageal reflux disease (GERD)
– Peptic ulcer disease
– Functional dyspepsia
– Gastritis-related symptoms
It effectively manages heartburn, acid regurgitation, epigastric discomfort, nausea, and bloating through its dual mechanism of action.

Administration Guidelines

For optimal results:
1. Take one capsule daily with water before breakfast
2. Swallow whole – do not crush, chew, or break
3. Maintain consistent dosing times
4. Continue treatment as prescribed, even if symptoms improve
5. Consult your physician before altering dosage regimen

Mechanism of Action

The therapeutic effects are achieved through:
1. Omeprazole: Permanently blocks H+/K+ ATPase enzymes in gastric parietal cells, significantly reducing acid production for up to 24 hours
2. Domperidone: Dopamine D2 receptor antagonist that:
– Accelerates gastric emptying
– Enhances lower esophageal sphincter tone
– Reduces nausea through chemoreceptor trigger zone inhibition

Dosage Protocol

Standard adult dosage:
– 1 sustained-release capsule (Omeprazole 20mg + Domperidone 30mg) once daily
Special populations:
– Hepatic impairment: Dose adjustment may be required
– Renal impairment: Caution advised
– Elderly: Monitor for adverse effects

Therapeutic Advantages

Key benefits include:
– 24-hour acid control with single daily dosing
– Simultaneous management of acid secretion and motility issues
– Improved medication compliance due to sustained-release formulation
– Rapid onset of symptom relief (within 1 hour for Domperidone component)
– Protective effect on esophageal mucosa

Adverse Effects

Most commonly reported effects (incidence >1%):
– Central nervous system: Headache (3.2%), dizziness (1.8%)
– Gastrointestinal: Diarrhea (2.1%), abdominal pain (1.5%), constipation (1.2%)
– Other: Fatigue (1.3%), dry mouth (1.0%)
These are typically mild and self-limiting within 2-3 days of continued use.

Precautions

Important safety considerations:
– Contraindicated in patients with:
– Known hypersensitivity to components
– Prolactin-releasing pituitary tumors
– Severe hepatic impairment
– Use caution with:
– Cardiac conditions (monitor QT interval)
– Electrolyte imbalances
– Concurrent CYP3A4 inhibitors
– Pregnancy/Lactation: Category C – use only if potential benefit justifies risk

Storage Conditions

Maintain product integrity by:
– Storing at controlled room temperature (15-30°C)
– Protecting from moisture and light
– Keeping in original packaging until use
– Properly disposing expired medication
– Never storing in bathroom or kitchen cabinets

Medical Disclaimer

This information serves educational purposes only and does not constitute medical advice. While we strive for accuracy, individual responses to medication may vary. Always:
– Disclose your complete medical history to prescribing physician
– Report all concurrent medications (including OTC products)
– Seek immediate medical attention for unusual symptoms
– Never share prescription medications
– Follow up regularly with your healthcare provider during treatment