P-Nolol SR

Product Overview

P-Nolol SR is a sustained-release tablet formulation containing Propranolol Hydrochloride as its active ingredient. This specialized delivery system ensures gradual medication release into the bloodstream, maintaining consistent therapeutic levels for 24-hour efficacy with single daily dosing. As a non-selective beta-adrenergic blocking agent, Propranolol Hydrochloride inhibits adrenaline’s effects on cardiac and vascular beta-receptors, effectively reducing heart rate and blood pressure.

Therapeutic Applications

Clinically indicated for:
– Management of essential hypertension
– Prophylaxis of angina pectoris
– Control of cardiac arrhythmias (particularly supraventricular tachycardias)
– Migraine prophylaxis
– Symptomatic treatment of anxiety disorders
– Secondary prevention post-myocardial infarction
Off-label uses may be considered at physician’s discretion based on individual patient assessment.

Administration Guidelines

Oral administration with water is recommended, preferably at consistent times daily. Tablets must be swallowed intact – crushing, chewing, or dividing compromises the sustained-release mechanism. Abrupt discontinuation is contraindicated; dose tapering under medical supervision is required to prevent rebound phenomena. Therapeutic response monitoring should include regular blood pressure and heart rate assessments.

Mechanism of Action

Propranolol Hydrochloride competitively blocks β1 and β2 adrenergic receptors, producing:
– Negative chronotropic and inotropic cardiac effects
– Reduced myocardial oxygen demand
– Decreased renin secretion
– Altered sympathetic nervous system activity
The matrix-based SR formulation provides first-order release kinetics, maintaining plasma concentrations within therapeutic range throughout the dosing interval.

Dosage Protocol

Individualized dosing based on:
– Therapeutic indication
– Patient response
– Tolerance profile
Standard hypertension protocol initiates with 80 mg once daily, titratable to 160 mg based on therapeutic response. Angina management typically requires 80-320 mg daily in divided doses. Close medical supervision is mandatory during dosage adjustments.

Therapeutic Advantages

Key benefits include:

• 24-hour hemodynamic control with single-dose convenience
• Cardioprotective effects in post-MI patients
• Prophylactic efficacy in migraine management
• Anxiolytic properties without CNS depression
• Improved medication adherence through sustained delivery

Adverse Effect Profile

Common reactions (incidence >1%):
– Fatigue
– Vertigo
– Gastrointestinal disturbances
– Sleep disturbances
Serious adverse effects requiring immediate medical attention include bradycardia, bronchospasm, and signs of hepatic dysfunction. A comprehensive risk-benefit assessment should precede therapy initiation.

Precautions and Contraindications

Special populations requiring careful monitoring:
– Asthmatics (bronchoconstriction risk)
– Diabetics (masked hypoglycemia)
– Hepatic impairment patients (reduced metabolism)
Absolute contraindications include:
– Cardiogenic shock
– Sinus bradycardia
– Advanced AV block
– Decompensated heart failure

Storage Requirements

Maintain at controlled room temperature (15-30°C) in original packaging. Protect from moisture and excessive heat. Ensure proper disposal of expired medication.

Medical Disclaimer

This information serves educational purposes only and does not constitute medical advice. Healthcare providers should be consulted for:
– Individual treatment plans
– Potential drug interactions
– Comprehensive risk assessments
– Management of adverse effects
This content supports but does not replace professional medical judgment. Always verify information with current prescribing resources.