Pentab

Product Overview

Pentab is a pharmaceutical formulation containing Pantoprazole Gastro-Resistant as its active component. Classified as a proton pump inhibitor (PPI), this medication functions by suppressing gastric acid secretion. The gastro-resistant formulation ensures the tablet remains intact through the stomach before dissolving in the small intestine, enabling targeted drug delivery and optimized therapeutic efficacy.

Uses

This medication is indicated for the management of acid-related disorders including:
– Gastroesophageal reflux disease (GERD)
– Peptic ulcer disease
– Erosive esophagitis
– NSAID-associated ulcer prophylaxis
– Pathological hypersecretory conditions

Pentab effectively alleviates symptoms such as pyrosis, acid regurgitation, and dyspepsia through gastric acid suppression.

How to Use

Administration Guidelines:
1. Take orally once daily before morning meal
2. Swallow tablet whole with water (do not chew/crush)
3. Maintain consistent dosing schedule
4. For patients with dysphagia: may administer with soft food (applesauce/yogurt)
5. Avoid concomitant administration with other liquids

How it Works

Pentab exerts its therapeutic effect through irreversible inhibition of the H+/K+-ATPase enzyme system (proton pump) in gastric parietal cells. This action:
– Reduces basal and stimulated acid secretion
– Decreases gastric fluid volume
– Lowers hydrogen ion concentration
– Creates favorable conditions for mucosal healing

Dosage and Administration

Standard Dosage Regimen:
– Initial: 20-40 mg once daily
– Maintenance: Adjust per clinical response
– Administration timing: Preprandial (preferably morning)

Special Populations:
– Hepatic impairment: Dose adjustment may be required
– Elderly: No specific adjustment needed
– Pediatrics: Safety not established

Benefits

Therapeutic Advantages:
– Rapid symptom relief
– Promotes ulcer healing
– Prevents ulcer recurrence
– Improves quality of life
– Reduces acid-related complications
– Maintains remission in GERD

Common Side Effects

Frequently Reported Adverse Effects (≥1%):
– Cephalgia
– Diarrhea
– Nausea
– Abdominal discomfort
– Flatulence

Less Common Effects:
– Dizziness
– Rash
– Fatigue
– Constipation

Warnings

Important Safety Considerations:
– Long-term use may increase fracture risk
– May cause hypomagnesemia (especially with prolonged therapy)
– Potential for vitamin B12 malabsorption
– Increased susceptibility to gastrointestinal infections
– Drug interactions with:
– Warfarin
– Ketoconazole
– Iron salts
– Methotrexate

Contraindications:
– Hypersensitivity to PPIs
– Concomitant use with rilpivirine-containing products

Storage Information

Storage Requirements:
– Temperature: 20-25°C (68-77°F)
– Protect from moisture and light
– Keep in original packaging
– Store in secure location away from children
– Properly dispose expired/unused medication

Disclaimer:

The information provided herein is intended for educational purposes only and represents current medical knowledge at the time of publication. This content does not constitute medical advice and should not replace professional clinical judgment. Healthcare providers should be consulted for:
– Individualized treatment plans
– Complete safety information
– Potential drug interactions
– Comprehensive adverse effect profiles
– Specific contraindications

This material aims to supplement, not substitute, the essential relationship between healthcare providers and their patients. Always verify information with current prescribing literature before clinical application.