Pentasa Suppositories

Product Overview

Pentasa Suppositories contain the active ingredient Mesalazine (also known as mesalamine) and are formulated for rectal administration. As part of the aminosalicylate class of medications, these suppositories are specifically designed to treat inflammatory bowel diseases (IBD) like ulcerative colitis and Crohn’s disease. The rectal delivery system ensures targeted medication release directly to inflamed areas in the rectum and lower colon, providing localized relief from IBD symptoms and inflammation.

Uses

These suppositories are indicated for managing mild-to-moderate flare-ups of ulcerative colitis, a chronic IBD causing inflammation and ulcers in the colon and rectal lining. By delivering Mesalazine precisely to affected tissues, they help reduce inflammation, alleviate symptoms including rectal bleeding and diarrhea, and support healing of the intestinal mucosa.

How to Use

For proper administration:
1. Thoroughly wash hands with soap and water
2. Remove suppository from packaging and moisten with water for easier insertion
3. Lie on your side with lower leg straight and upper leg bent toward stomach
4. Gently insert suppository into rectum (pointed end first)
5. Remain lying down for several minutes to allow complete dissolution
6. Wash hands again after administration

How it Works

Mesalazine exerts its therapeutic effect locally by:
– Inhibiting production of pro-inflammatory compounds
– Promoting anti-inflammatory substances
– Modulating the inflammatory response
This mechanism helps relieve characteristic ulcerative colitis symptoms including abdominal pain, diarrhea, and rectal bleeding. The rectal administration ensures optimal drug concentration at the site of inflammation.

Dosage and Administration

Standard dosage is one 1g suppository administered rectally once daily, preferably at bedtime. Dosage adjustments may be made based on:
– Disease severity
– Individual treatment response
– Healthcare provider’s assessment
Always follow your physician’s prescribed regimen for optimal therapeutic outcomes.

Benefits

Key advantages include:
– Targeted drug delivery to affected areas
– Effective symptom relief (rectal bleeding, diarrhea, pain)
– Reduced frequency and intensity of flare-ups
– Improved quality of life for IBD patients
– Localized treatment with minimal systemic effects

Common Side Effects

Most frequently reported effects (typically mild and transient):
– Rectal discomfort/irritation
– Mild abdominal pain
– Headache
– Nausea
Consult your healthcare provider if these persist or worsen.

Warnings

Important precautions:
– Contraindicated in patients with Mesalazine/aminosalicylate hypersensitivity
– Disclose all medical conditions and current medications
– Pregnancy/breastfeeding: consult physician for risk-benefit analysis
– Monitor for allergic reactions (rash, difficulty breathing)

Storage Information

Proper storage guidelines:
– Maintain at room temperature (15-30°C)
– Protect from moisture and heat
– Keep in original packaging
– Store out of children’s and pets’ reach
– Discard if packaging is compromised or suppositories appear abnormal

Disclaimer:

While we strive to provide accurate, expert-reviewed information, this content should not replace professional medical advice. The information presented here is for educational purposes only and may not encompass all potential side effects, interactions, or contraindications. Always consult your healthcare provider regarding any medical condition or treatment. Our goal is to supplement, not substitute, the crucial doctor-patient relationship.