Prilox Cream

Product Overview

Prilox Cream is a topical anesthetic formulation combining Lidocaine and Prilocaine as active ingredients. This dual-action cream is clinically proven for surface anesthesia prior to medical interventions including injections, minor surgical procedures, and dermatological treatments. Available in multiple therapeutic strengths, Prilox Cream provides targeted analgesia when applied to intact skin surfaces.

Therapeutic Applications

This anesthetic preparation is indicated for:
– Pre-procedural skin anesthesia in clinical settings
– Pain management during venipuncture, laser therapy, and superficial surgical procedures
– Symptomatic relief of dermal discomfort from minor abrasions, thermal burns, or insect stings
– Adjuvant therapy in dermatological and dental procedures requiring localized analgesia

Application Protocol

For optimal efficacy:
1. Cleanse and dry target area thoroughly
2. Apply uniform thin layer (1-2mm) without occlusion
3. Maintain application for 30-60 minutes pre-procedure
4. Remove residual cream prior to intervention
Note: Specific application parameters should be determined by the treating physician based on procedural requirements.

Mechanism of Action

The synergistic action of Lidocaine (amide anesthetic) and Prilocaine (aminoamide anesthetic) achieves:
– Voltage-gated sodium channel blockade in peripheral neurons
– Inhibition of depolarization and action potential propagation
– Reversible sensory nerve conduction blockade
– Onset within 30 minutes with duration of 1-2 hours post-removal

Dosing Guidelines

Standard dosing parameters:
– Adults: 1-2g per 10cm² skin surface
– Pediatric: Reduced dosing under medical supervision
– Maximum application area: <200cm² in adults - Application duration: Minimum 60 minutes for full effect Therapeutic Advantages

Clinical benefits include:
– Rapid-onset, reversible local anesthesia
– Non-invasive pain management solution
– Enhanced patient comfort during procedures
– Reduced procedural anxiety
– Minimal systemic absorption when properly applied

Adverse Effects

Common transient reactions may include:
– Application site erythema (15-20% incidence)
– Mild edema (5-10% incidence)
– Transient pallor or temperature changes
Serious reactions (rare <1%): - Contact dermatitis - Methemoglobinemia (risk factors: infants, G6PD deficiency) - Systemic absorption symptoms Precautions

Contraindications and warnings:
– Avoid application to mucous membranes or compromised skin
– Contraindicated in patients with:
– Known ester anesthetic hypersensitivity
– Congenital methemoglobinemia
– Severe hepatic impairment
– Special precautions required for:
– Pediatric patients
– Elderly population
– Pregnancy/lactation (Category B)

Storage Conditions

Optimal storage parameters:
– Temperature: 15-30°C
– Protection from:
– Light exposure
– Humidity
– Extreme temperatures
– Shelf life: 24 months from manufacture
– Child-resistant packaging mandatory

Medical Disclaimer

This informational content is developed through rigorous pharmacological review processes. However:
1. Not a substitute for professional medical advice
2. Does not encompass all potential clinical scenarios
3. Physician consultation mandatory before use
4. Intended to supplement, not replace, clinical judgment
5. Report adverse events to local pharmacovigilance authorities