Nurofen

Product Overview

Brufen is an ibuprofen-based medication classified as a nonsteroidal anti-inflammatory drug (NSAID). Available in multiple formulations including oral tablets, capsules, suspension, and topical preparations, it effectively manages pain, reduces inflammation, and alleviates fever associated with various conditions such as headaches, dental pain, dysmenorrhea, musculoskeletal discomfort, arthritis, and minor trauma.

Uses

This medication provides symptomatic treatment for mild-to-moderate pain syndromes including cephalalgia, odontalgia, primary dysmenorrhea, and myalgia. It demonstrates anti-inflammatory efficacy in arthritic conditions (osteoarthritis, rheumatoid arthritis), soft tissue disorders (tendinitis, bursitis), and minor musculoskeletal injuries. Brufen also exhibits antipyretic properties for febrile states accompanying influenza and upper respiratory infections.

How to Use

Administer oral formulations with adequate hydration. Dosage regimens should be individualized based on symptom severity, patient characteristics, and clinical indication. Strictly adhere to prescribing instructions. Topical applications require gentle massage into affected areas until complete absorption occurs. Exceeding recommended dosages or treatment durations without medical supervision is contraindicated.

How it Works

The pharmacodynamic action involves competitive inhibition of cyclooxygenase isoenzymes (COX-1/COX-2), thereby suppressing prostaglandin biosynthesis. This mechanism produces analgesic, anti-inflammatory, and antipyretic effects through modulation of inflammatory mediators and central thermoregulatory pathways.

Dosage and Administration

Adult dosing typically initiates with 200-400 mg every 4-6 hours (maximum 3200 mg/24h). Pediatric dosing follows weight-based calculations (5-10 mg/kg/dose, not exceeding 40 mg/kg/day). Clinical practice emphasizes using the minimal effective dose for the shortest necessary duration to achieve therapeutic goals while mitigating adverse effect risks.

Benefits

1. Multimodal therapeutic effects addressing pain, inflammation, and pyrexia
2. Versatile administration options (oral/systemic and topical/local delivery)
3. Rapid pharmacokinetic profile with therapeutic onset within 30-60 minutes post-administration
4. Favorable safety profile when used within recommended dosing parameters
5. Broad clinical applicability across multiple pain and inflammatory conditions

Common Side Effects

Gastrointestinal manifestations (dyspepsia, epigastric discomfort, nausea, diarrhea) represent the most frequent adverse reactions. These typically demonstrate mild, self-limiting characteristics. Chronic use or supratherapeutic dosing elevates risks for peptic ulceration, gastrointestinal hemorrhage, and nephrotoxicity. Immediate medical evaluation is warranted for hematemesis, melena, or renal impairment symptoms.

Warnings

Exercise caution in patients with:

• History of peptic ulcer disease or gastrointestinal bleeding
• Renal insufficiency or cardiac compromise
• Third trimester pregnancy (potential fetal complications)

Concomitant ethanol consumption may potentiate gastrointestinal irritation. CNS effects (dizziness, somnolence) may impair psychomotor performance. Comprehensive medication review is essential prior to initiation, particularly in patients with comorbidities or complex pharmacotherapy regimens.

Storage Information

Maintain at controlled room temperature (15-30°C) in original packaging, protected from humidity and light exposure. Implement appropriate child-resistant storage measures. Discard compromised or expired products according to regional pharmaceutical waste disposal guidelines.

Disclaimer:

This informational content undergoes rigorous medical review to ensure accuracy and reliability. However, it does not substitute professional medical advice, diagnosis, or treatment. The presented information may not encompass all potential adverse effects, contraindications, or drug interactions. Healthcare providers should be consulted for personalized therapeutic recommendations. This resource aims to facilitate, not replace, clinician-patient relationships.