This medication serves as prophylactic treatment to prevent postoperative infections and is also indicated for odontogenic infections, lower extremity ulcers, and decubitus ulcers. For optimal absorption, administer with meals at consistent daily intervals. Dosage varies based on infection type and severity – strict adherence to prescribed regimen is crucial. Continue full course even after symptom resolution to prevent bacterial persistence and recurrence. Avoid alcohol consumption during treatment and for 72 hours post-therapy to prevent disulfiram-like reactions (nausea, emesis, abdominal discomfort).
Common adverse effects include cephalalgia, xerostomia, nausea, and dysgeusia (metallic taste). These typically resolve spontaneously; consult your healthcare provider if persistent. Sugar-free lozenges may alleviate oral symptoms.
Contraindications include hypersensitivity to nitroimidazole derivatives. Exercise caution in patients with hepatic/renal impairment or neurological disorders. Pregnancy and lactation status should be disclosed before initiation.
THERAPEUTIC INDICATIONS
- Bacterial infections
- Protozoal infections
CLINICAL BENEFITS
Antimicrobial Efficacy
The bactericidal mechanism involves inhibition of nucleic acid synthesis through free radical generation. While symptomatic improvement often occurs rapidly, complete prescribed course completion is essential to prevent antimicrobial resistance development. Teratogenic risk appears minimal based on current evidence, but obstetric consultation is recommended before prescribing to pregnant patients.
ADVERSE EFFECTS PROFILE
Frequently reported reactions
- Cephalalgia
- Xerostomia
- Nausea
- Dysgeusia
ADMINISTRATION GUIDELINES
Medical Disclaimer:
This content is provided for educational purposes only and represents expert-reviewed pharmacological information. It is not intended as medical advice or to replace professional clinical judgment. The complete prescribing information including contraindications, warnings, and potential drug interactions may not be fully represented. Healthcare providers should be consulted for personalized therapeutic recommendations and to address specific clinical questions. This information aims to facilitate informed patient-provider discussions, not to supersede them.
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