Flexabenz Gel

Product Overview

Flexabenz Gel is a topical analgesic formulation combining Diclofenac Diethylamine, Linseed Oil, Methyl Salicylate, Menthol, and Cyclobenzaprine Hydrochloride. Designed for localized treatment of musculoskeletal disorders, this transdermal gel offers rapid absorption and targeted delivery of active ingredients to affected areas. The synergistic blend provides multi-modal action against pain, inflammation, and muscle spasms, making it particularly effective for various musculoskeletal complaints.

Therapeutic Indications

This topical preparation is clinically indicated for symptomatic management of:
– Arthritic conditions (osteoarthritis, rheumatoid arthritis)
– Mechanical back pain
– Acute musculoskeletal injuries (sprains, strains)
– Sports-related trauma
– Myofascial pain syndromes
The formulation is approved for use in patients aged 12 years and above, offering localized therapy while minimizing systemic exposure.

Application Guidelines

1. Clean and dry the affected area before application
2. Dispense 2-4 cm of gel (depending on treatment area)
3. Gently massage into skin until fully absorbed
4. Wash hands post-application
5. Frequency: 3-4 times daily or as medically directed
Contraindications include application to damaged skin, mucous membranes, or periocular areas. Occlusive dressings should not be used unless specifically prescribed.

Mechanism of Action

The pharmacological effects are achieved through:
1. Diclofenac Diethylamine: NSAID component inhibiting cyclooxygenase enzymes (COX-1/COX-2), reducing prostaglandin-mediated inflammation
2. Methyl Salicylate: Counterirritant producing vasodilation and analgesic effects
3. Menthol: TRPM8 receptor agonist providing cooling analgesia
4. Linseed Oil: Omega-3 fatty acids with anti-inflammatory properties
5. Cyclobenzaprine: Centrally-acting muscle relaxant (when systemically absorbed)

Dosage Protocol

Recommended therapeutic regimen:
– Adults and adolescents (≥12 years): Apply 2-4 cm gel to affected area 3-4 times daily
– Maximum daily dose: 16 cm gel (approximately 160 mg diclofenac)
– Treatment duration: Not to exceed 7 days without medical supervision
Special populations (renal/hepatic impairment) should use with caution and medical guidance.

Therapeutic Advantages

Key clinical benefits include:
– Targeted delivery with minimal systemic absorption
– Rapid onset of action (typically within 30 minutes)
– Multi-modal mechanism addressing pain, inflammation, and muscle spasm
– Favorable safety profile compared to oral NSAIDs
– Convenient application suitable for outpatient use

Adverse Effects

Common local reactions (incidence >1%):
– Transient erythema
– Pruritus
– Burning sensation
– Contact dermatitis
Serious reactions requiring discontinuation:
– Severe skin reactions (exfoliative dermatitis)
– Bronchospasm (in aspirin-sensitive patients)
– Photosensitivity reactions

Precautions and Contraindications

Absolute contraindications:
– Hypersensitivity to any component
– Third trimester pregnancy
– History of aspirin-induced asthma
Special precautions:
– Avoid concurrent use with other topical NSAIDs
– Monitor for skin reactions
– Sun protection advised during treatment
– Caution in elderly patients

Storage Conditions

Optimal storage parameters:
– Temperature: 15-30°C
– Protection from light and moisture
– Secure container closure
– Shelf life: 24 months from manufacture
Disposal should follow local pharmaceutical waste regulations.

Medical Disclaimer

This product information is intended for healthcare professionals and informed consumers. The content undergoes regular medical review but does not replace professional judgment. Healthcare providers should consider individual patient factors when prescribing. Patients should report any adverse reactions to their physician. This information may not include all possible interactions or contraindications. Always consult a qualified medical practitioner for personalized advice.