Valprol-CR

Product Overview

Valprol-CR is a pharmaceutical formulation containing the active components Sodium Valproate and Valproic Acid. Presented as an extended-release tablet, this medication is engineered to provide gradual drug delivery. Valprol-CR is clinically indicated for the management of epilepsy, bipolar affective disorder, and migraine prophylaxis. The product is manufactured in various dosage strengths to meet individualized therapeutic requirements and is administered orally, with or without food.

Therapeutic Indications

Valprol-CR is extensively utilized in neurological and psychiatric therapeutics. Its primary application involves seizure control in epilepsy through stabilization of cerebral electrical activity. The medication is also prescribed for mood stabilization in bipolar disorder and for preventive management of migraine headaches to decrease attack frequency and intensity.

Administration Guidelines

Valprol-CR must be taken in strict accordance with medical prescription. Tablets should be ingested whole with adequate water, preferably during meals to mitigate potential gastrointestinal effects. The controlled-release formulation must not be crushed, chewed, or divided to maintain its pharmacological properties. Dosage regimen is individualized based on clinical assessment of the patient’s condition, therapeutic response, and other relevant medical factors.

Mechanism of Action

The active constituents of Valprol-CR exert their therapeutic effect by potentiating gamma-aminobutyric acid (GABA) neurotransmission, an inhibitory neurotransmitter system. This pharmacological action modulates neuronal excitability, thereby preventing pathological electrical discharges associated with seizure disorders and mood instability in bipolar conditions.

Dosage Protocol

Valprol-CR dosing is titrated according to patient-specific parameters including age, body mass, clinical indication, and treatment response. Therapy typically commences with lower doses, with gradual upward titration to achieve optimal therapeutic effect while monitoring tolerability. The extended-release formulation permits once or twice-daily administration, with total daily dose divided to maintain consistent plasma concentrations. Dose modifications should be physician-supervised.

Therapeutic Advantages

• Clinically proven efficacy in epilepsy, bipolar disorder, and migraine management
• Modified-release technology ensures sustained pharmacological activity
• Simplified dosing schedule enhances patient compliance
• Provides seizure control, mood stabilization, and migraine prophylaxis
• Multiple strength options available for personalized treatment

Adverse Effects

Common adverse reactions associated with Valprol-CR therapy may include somnolence, vertigo, gastrointestinal disturbances (nausea, vomiting, diarrhea), weight fluctuations, and alopecia. These effects are generally mild and often resolve with continued therapy or dosage adjustment. Serious adverse effects requiring immediate medical intervention include hepatotoxicity, pancreatic inflammation, and hematological abnormalities.

Precautions

Valprol-CR requires careful monitoring in patients with hepatic impairment, pancreatic disorders, or hematological conditions due to potential exacerbation risks. Regular hepatic function assessments and hematological monitoring are essential during treatment. This medication is contraindicated in pregnancy due to teratogenic potential unless clinical benefit significantly outweighs risk. Concomitant alcohol use is contraindicated due to increased hepatotoxicity risk.

Storage Conditions

Maintain Valprol-CR at controlled room temperature, protected from humidity and heat sources. Store in child-resistant containers out of reach of children and pets. Discard expired or physically compromised tablets appropriately in accordance with pharmaceutical waste disposal guidelines.

Disclaimer:

The information provided is intended for educational purposes only and represents expert-reviewed, evidence-based data. This content does not substitute professional medical advice, diagnosis, or treatment. The complete safety profile, including potential drug interactions and contraindications, may not be fully detailed herein. Always consult with a qualified healthcare provider regarding any medical condition or therapeutic regimen. This information aims to complement, not replace, the crucial physician-patient relationship.