Proluton Depot

Product Description

Proluton Depot is a hormonal medication containing Hydroxyprogesterone caproate as its active component. This prescription drug is formulated as an intramuscular injectable solution for various obstetric and gynecological applications.

Therapeutic Indications

Proluton Depot is clinically indicated for:
– Pregnancy maintenance in women with recurrent pregnancy loss
– Prevention of preterm delivery in high-risk pregnancies
– Management of specific progesterone deficiency conditions
– Treatment of selected hormonal disorders

Administration Guidelines

This medication must be administered by qualified healthcare personnel through deep intramuscular injection, typically in the gluteal or deltoid muscle. The treatment regimen (dosage and frequency) will be individually tailored by your physician based on:
– Your medical history
– Specific clinical indication
– Treatment response
– Risk factors

Always adhere to the prescribed administration schedule and never modify the dosage without medical supervision.

Mechanism of Action

The active compound, Hydroxyprogesterone caproate, is a synthetic progestin that:
1. Modulates endometrial receptivity
2. Maintains uterine quiescence
3. Supports placental function
4. Regulates hormonal balance
These pharmacological actions collectively create an optimal uterine environment for pregnancy continuation.

Therapeutic Advantages

Clinical benefits of Proluton Depot therapy include:
✔ Enhanced pregnancy maintenance
✔ Reduced incidence of preterm delivery
✔ Improved hormonal regulation
✔ Better pregnancy outcomes in high-risk cases

Adverse Effects

While generally well-tolerated, potential adverse reactions may include:
– Local reactions at injection site (pain, erythema, induration)
– Menstrual irregularities
– Breast discomfort
– Emotional lability
– Mild fluid retention

Most side effects are transient and mild in nature. Persistent or severe reactions warrant immediate medical consultation.

Treatment Protocol

The therapeutic regimen involves:
– Precise dosing as determined by your obstetrician
– Strict adherence to injection intervals
– Regular clinical monitoring
– Periodic treatment evaluation

Never self-administer or alter the prescribed treatment schedule.

Precautions and Contraindications

Important safety considerations:
⚠ Disclose complete medical history (especially thromboembolic disorders or hepatic impairment)
⚠ Report concurrent medications (including OTC products)
⚠ Notify about known drug allergies
⚠ Immediate reporting of unusual symptoms

Absolute contraindications include:
– Active thrombophlebitis
– History of progesterone-sensitive malignancies
– Undiagnosed vaginal bleeding
– Severe hepatic dysfunction

Storage Information

As a healthcare professional-administered medication, storage and handling are managed by medical facilities under controlled conditions maintaining:
– Appropriate temperature ranges
– Protection from light
– Proper aseptic techniques
– Quality control measures