Fiorinal

Product Overview

Sibelium is a pharmaceutical preparation containing Flunarizine Dihydrochloride as its active component. Classified as a calcium channel blocker, this medication is principally indicated for migraine prophylaxis. It functions by inhibiting calcium ion entry into smooth muscle cells and neurons, resulting in cellular membrane stabilization and decreased migraine attack frequency and intensity. The product is formulated as oral tablets for convenient administration.

Therapeutic Applications

This medication is prescribed for migraine prevention in patients experiencing recurrent or severe migraine episodes. It demonstrates particular efficacy in managing migraine with aura symptoms, including visual disturbances or sensory alterations. Additionally, it may be utilized in treating vestibular conditions such as vertigo and Meniere’s disease, owing to its capacity to modulate inner ear pressure and vestibular system activity.

Administration Guidelines

The tablets should be taken orally according to medical prescription. Standard dosing involves one tablet (5-10 mg) administered once daily, preferably at bedtime. Tablets must be swallowed intact with adequate water – crushing, chewing, or dividing is not recommended. Administration may occur with or without food. Strict adherence to prescribed dosing is essential, and dosage adjustments should only be made under medical supervision.

Mechanism of Action

The therapeutic effect is achieved through selective calcium channel blockade, which modulates calcium ion influx into vascular smooth muscle cells and neurons. This pharmacological action stabilizes cellular membranes and reduces neuronal hyperexcitability in cerebral vasculature and neural pathways. By mitigating pathological electrical activity and vascular changes associated with migraine pathophysiology, the medication effectively decreases migraine occurrence and severity.

Dosage Protocol

Optimal dosing is individualized based on patient characteristics including age, clinical presentation, and therapeutic response. Standard regimen involves once-daily evening administration to minimize potential sedative effects. If a dose is missed, it should be taken when remembered unless approaching the next scheduled dose time, in which case the missed dose should be omitted to maintain regular dosing intervals.

Therapeutic Advantages

1. Effective migraine prophylaxis with reduction in attack frequency
2. Management of migraine with aura manifestations
3. Therapeutic intervention for vestibular disorders including vertigo
4. Modulation of inner ear pressure and vestibular function
5. Enhancement of daily functioning and quality of life

Adverse Effects

Common pharmacological effects may include somnolence, fatigue, body weight changes, and mood alterations. These typically represent transient, dose-dependent phenomena that may attenuate with continued therapy. Less frequent effects encompass dizziness, gastrointestinal symptoms, and changes in appetite or sexual function. Persistent or severe adverse reactions warrant medical consultation.

Precautions

Caution is advised in patients with depressive disorders due to potential mood effects. The medication may impair cognitive and motor performance, necessitating caution when operating vehicles or machinery. Concurrent alcohol consumption may potentiate central nervous system effects. Comprehensive medical history and current medication review should precede therapy initiation.

Storage Conditions

Maintain at controlled room temperature, protected from moisture and heat sources. Store in original packaging away from children and pets. Avoid storage in humid environments such as bathrooms. Dispose of expired or unused medication according to pharmaceutical waste regulations.

Medical Disclaimer

The provided information represents carefully reviewed, accurate medical content intended for educational purposes only. This content does not substitute professional medical advice, diagnosis, or treatment. Complete information regarding potential adverse effects, drug interactions, or contraindications may not be fully represented. Always consult qualified healthcare providers for medical guidance. This information aims to facilitate, not replace, the essential healthcare provider-patient relationship.