Ten of EM

Product Overview

Tenof EM is a combination antiretroviral therapy prescribed for managing HIV infection and chronic hepatitis B virus (HBV) infection. This fixed-dose combination contains Emtricitabine and Tenofovir, which work synergistically to inhibit viral replication. By suppressing HIV multiplication, the medication reduces viral load while increasing CD4 lymphocyte counts – crucial white blood cells that combat infections.

Uses

This medication serves as part of comprehensive treatment regimens for HIV/AIDS and chronic hepatitis B. While not curative, Tenof EM effectively suppresses viral activity when combined with other antiretrovirals. Clinical benefits include viral load reduction, immune system restoration through CD4 cell count improvement, and prevention of disease progression to AIDS-defining conditions.

How to Use

For optimal therapeutic outcomes, take Tenof EM exactly as prescribed, typically one tablet daily. Administration timing (with or without food) should remain consistent. Strict adherence to the prescribed regimen is critical for maintaining therapeutic drug levels and preventing viral resistance.

How it Works

The active components target reverse transcriptase, an essential enzyme for HIV replication. Emtricitabine and Tenofovir function as nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), disrupting the viral life cycle. This dual mechanism provides potent viral suppression while preserving immune function.

Dosage and Administration

Standard dosing consists of one oral tablet (200mg Emtricitabine/300mg Tenofovir disoproxil fumarate) daily. Swallow tablets whole with water, maintaining consistent daily dosing times. Renal function monitoring may necessitate dosage adjustments in patients with impaired kidney function.

Benefits

Clinical benefits include:
• Sustained HIV viral suppression
• Reduced transmission risk
• Improved immunological parameters
• Decreased incidence of opportunistic infections
• Slowed disease progression
• Enhanced quality of life

Common Side Effects

Frequently reported adverse effects (typically mild and transient) include:
• Gastrointestinal disturbances (nausea, diarrhea)
• Headache
• Fatigue
• Dizziness
• Mild renal function changes
Persistent or severe symptoms warrant medical evaluation.

Warnings

Important safety considerations:
• Contraindicated in severe renal impairment (CrCl <30mL/min) • Requires hepatic monitoring in patients with liver disease • Potential for lactic acidosis/hepatic steatosis • Risk of HBV reactivation upon discontinuation • Bone mineral density monitoring recommended • Potential for immune reconstitution syndrome

Storage Information

Store at controlled room temperature (20-25°C) in original packaging. Protect from moisture and light. Keep securely closed and out of reach of children. Do not use if packaging appears compromised.

Who is Tenof EM suitable for?

Indicated for:
• HIV-positive adults and adolescents (≥12 years, ≥17kg)
• Chronic HBV-infected patients (≥12 years)
• Pre-exposure prophylaxis (PrEP) candidates (off-label use)
• Post-exposure prophylaxis regimens

Who is Tenof EM not suitable for?

Contraindications include:
• Hypersensitivity to active ingredients
• Severe renal dysfunction
• Concurrent use with nephrotoxic agents
• Untreated osteopenia/osteoporosis
• Active lactic acidosis

Can you use Tenof EM if you are pregnant?

Pregnancy considerations:
• FDA Pregnancy Category B
• Risk-benefit assessment required
• Antiretroviral pregnancy registry monitoring recommended
• Potential for vertical transmission prevention

Can you use Tenof EM if you are breastfeeding?

Lactation advisory:
• Detectable in breastmilk
• HIV-positive mothers should avoid breastfeeding
• Alternative feeding methods recommended
• Individual risk assessment necessary

How does Tenof EM interact with other drugs?

Significant interactions occur with:
• Nephrotoxic agents (aminoglycosides, IV pentamidine)
• HIV protease inhibitors (boosted regimens)
• Adefovir dipivoxil
• Didanosine
• Certain antivirals (ganciclovir, valganciclovir)
Complete medication review with healthcare provider essential.

What warnings does Tenof EM come with?

Boxed warnings include:
1. Post-treatment acute HBV exacerbation
2. Lactic acidosis/severe hepatomegaly risk
3. Emerging antiviral resistance patterns
4. Renal impairment monitoring requirements

Purchase Information

Availability:
• Pharmacy dispensing with valid prescription
• Verified online pharmacy options
• Generic equivalents available
• Cold chain maintenance not required
Always verify product authenticity through regulatory authorities.

Disclaimer

This information serves educational purposes only and does not constitute medical advice. Healthcare providers should be consulted for:
• Individual treatment decisions
• Adverse event management
• Drug interaction assessments
• Therapeutic monitoring
The content represents current medical understanding but may not encompass all clinical considerations. Regular therapeutic reviews are recommended.