Valentine

Product Overview

Valent is a prescription medication containing the active pharmaceutical ingredient Valsartan. Formulated as oral tablets, it belongs to the therapeutic class of angiotensin II receptor blockers (ARBs). This pharmaceutical agent is primarily indicated for the management of hypertension (high blood pressure) and chronic heart failure. Its mechanism of action involves vasodilation of blood vessels, which enhances circulatory efficiency, reduces arterial pressure, and decreases cardiac workload.

Therapeutic Indications

Valent is clinically approved for:
– Treatment of essential hypertension
– Management of chronic heart failure (NYHA Class II-IV)
– Post-myocardial infarction cardiac dysfunction

The medication demonstrates efficacy in reducing cardiovascular morbidity and mortality by mitigating hypertension-related complications including cerebrovascular accidents, myocardial infarction, and renal impairment.

Administration Guidelines

For optimal therapeutic outcomes:
– Administer orally with water, with or without food
– Maintain consistent dosing schedule
– Strictly adhere to prescribed dosage regimen
– Do not discontinue therapy without medical consultation
– Gradual dose titration may be required based on therapeutic response

Pharmacological Mechanism

Valsartan exerts its therapeutic effect through selective antagonism of angiotensin II type 1 (AT1) receptors. This blockade prevents vasoconstriction mediated by the renin-angiotensin-aldosterone system (RAAS), resulting in:
– Peripheral arterial vasodilation
– Reduced systemic vascular resistance
– Decreased aldosterone secretion
– Improved cardiac output in heart failure patients

Dosage Protocol

Therapeutic dosing is individualized based on clinical indication and patient response:

Hypertension:
– Initial dose: 80 mg once daily
– Maintenance range: 80-320 mg daily
– Maximum dose: 320 mg daily

Heart Failure:
– Starting dose: 40 mg twice daily
– Target dose: 160 mg twice daily

Post-MI:
– Initial dose: 20 mg twice daily
– Titration to 160 mg twice daily

Therapeutic Advantages

Clinical benefits of Valent therapy include:
– Significant reduction in systolic and diastolic blood pressure
– Improved cardiac function in heart failure patients
– Reduced hospitalization rates for cardiac decompensation
– Decreased cardiovascular mortality
– Renoprotective effects in hypertensive patients

Adverse Effects

Common adverse reactions (≥1% incidence):
– Dizziness (17%)
– Vertigo (8%)
– Headache (5%)
– Fatigue (3%)
– Abdominal discomfort (2%)

Serious but rare complications:
– Hyperkalemia (serum K+ >5.5 mEq/L)
– Angioedema (<0.1%) - Hepatotoxicity (0.01%) - Acute renal impairment

Precautions and Contraindications

Absolute contraindications:
– Pregnancy (FDA Category D)
– History of angioedema with ARBs
– Severe hepatic impairment (Child-Pugh C)
– Concomitant aliskiren use in diabetic patients

Special precautions:
– Renal function monitoring required
– Potassium level assessment necessary
– Caution in bilateral renal artery stenosis
– Avoid in hypotensive patients

Storage Requirements

– Store at controlled room temperature (20-25°C)
– Protect from moisture and light
– Keep in original packaging
– Maintain out of children’s reach
– Properly dispose expired medication

Medical Disclaimer

The information provided herein is for educational purposes only and does not constitute medical advice. This monograph does not replace professional medical judgment or comprehensive product prescribing information. Healthcare providers should reference the full prescribing information for complete details regarding contraindications, warnings, drug interactions, and adverse effects. Patients should consult qualified healthcare professionals for personalized medical recommendations. This content is intended to supplement, not substitute, the physician-patient relationship.