Bicyphage 1000 SR

Product Overview

Biciphage 1000 SR is a sustained-release formulation containing 1000 mg of Metformin, designed for the management of type 2 diabetes. This extended-release tablet provides continuous glucose control with once-daily dosing, offering improved patient compliance and reduced gastrointestinal side effects compared to immediate-release formulations. By enhancing insulin sensitivity and decreasing hepatic glucose production, Biciphage 1000 SR helps maintain optimal blood sugar levels in patients who haven’t achieved adequate control through lifestyle modifications alone.

Uses

Biciphage 1000 SR is indicated for:

• Management of type 2 diabetes mellitus in adults
• Improving glycemic control when diet and exercise prove insufficient
• Combination therapy with other antidiabetic agents when needed
• Off-label use for polycystic ovary syndrome (PCOS) management

This medication helps prevent diabetes-related complications including neuropathy, nephropathy, and cardiovascular diseases by maintaining stable blood glucose levels.

How to Use

1. Take exactly as prescribed, typically once daily with the evening meal
2. Swallow tablet whole with water – do not crush, chew, or break
3. Maintain consistent dosing schedule
4. If a dose is missed, take as soon as remembered unless near next dose time
5. Never take double doses to compensate for missed ones

Mechanism of Action

Biciphage 1000 SR exerts its antidiabetic effects through:

• Suppression of hepatic gluconeogenesis
• Enhancement of peripheral glucose uptake
• Improvement of insulin sensitivity
• Delayed intestinal glucose absorption

The sustained-release technology ensures gradual drug release, maintaining therapeutic concentrations over 24 hours.

Dosage and Administration

Dose adjustments may be required based on renal function and therapeutic response.

Benefits

• 24-hour glycemic control with single daily dosing
• Reduced GI side effects compared to immediate-release formulations
• Cardiovascular protective effects in diabetic patients
• Weight-neutral profile, unlike many other antidiabetic agents
• Cost-effective first-line therapy for type 2 diabetes

Common Side Effects

Most side effects are gastrointestinal and typically transient:

• Nausea (10-25%)
• Diarrhea (10-20%)
• Abdominal discomfort (5-10%)
• Metallic taste (3-5%)
• Decreased vitamin B12 absorption (long-term use)

Important Safety Information

Contraindications:

• Severe renal impairment (eGFR <30 mL/min)
• Acute or chronic metabolic acidosis
• Hypersensitivity to metformin

Precautions:

• Monitor renal function annually
• Temporarily discontinue before radiocontrast procedures
• Caution in hepatic impairment
• Avoid excessive alcohol intake

Storage Conditions

• Store below 25°C (77°F)
• Protect from moisture and light
• Keep in original packaging
• Keep out of reach of children

Patient Counseling

• Continue dietary and exercise regimen
• Recognize symptoms of lactic acidosis
• Monitor blood glucose regularly
• Report unusual muscle pain or weakness
• Attend all follow-up appointments

Disclaimer

This information is provided for educational purposes only and does not constitute medical advice. Always consult your healthcare provider for personalized medical recommendations. The manufacturer is not responsible for any consequences arising from the use of this information. Report any adverse events to your local health authority.